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MicroRNAs in Cardiovascular Disease: From Pathogenesis to Treatment

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Pathophysiology and Pharmacotherapy of Cardiovascular Disease

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Abstract

Cardiovascular diseases are among the major causes of morbidity and mortality worldwide. Currently, considerable effort is made to intensify preventive measures, refine diagnostic testing, and advance therapeutic strategies. In this context, miRNAs have emerged as a new class of key regulators involved in the pathogenesis of many cardiovascular disorders, entailing a deep scientific interest in assessing their biomedical potential. Numerous studies identified miRNA signatures that correlate with specific cardiovascular conditions, hereby emphasizing their potential as molecular biomarkers. In the therapeutic setting, modulations of miRNA expression and function in experimental models of cardiac hypertrophy and heart failure are promising approaches. The encouraging results of these proof-of-concept studies and first successful clinical trials in humans point to a bright future for miRNAs in cardiovascular medicine.

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Authors and Affiliations

  1. Department of Internal Medicine III, University of Heidelberg, University Hospital of Heidelberg, Im Neuenheimer Feld 669, 69120, Heidelberg, Germany

    Ioana Barb MD, Britta Vogel MD, Hugo A. Katus MD & Benjamin Meder MD

  2. DZHK (German Centre for Cardiovascular Research), Heidelberg, Germany

    Hugo A. Katus MD & Benjamin Meder MD

  3. Klaus Tschira Institute for Computational Cardiology, University of Heidelberg, Heidelberg, Germany

    Hugo A. Katus MD & Benjamin Meder MD

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  1. Ioana Barb MD
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  2. Britta Vogel MD
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  3. Hugo A. Katus MD
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  4. Benjamin Meder MD
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Correspondence to Benjamin Meder MD .

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Editors and Affiliations

  1. Center for Drug Evaluation and Research Division of Cardiovascular and Renal Products, US Food and Drug Administration, Silver Spring, Maryland, USA

    Gowraganahalli Jagadeesh

  2. Pharmacology Unit, AIMST University, Bedong, Malaysia

    Pitchai Balakumar

  3. Center for Drug Evaluation and Research Division of Cardiovascular and Renal Products, US Food and Drug Administration, Silver Spring, Maryland, USA

    Khin Maung-U

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Barb, I., Vogel, B., Katus, H.A., Meder, B. (2015). MicroRNAs in Cardiovascular Disease: From Pathogenesis to Treatment. In: Jagadeesh, G., Balakumar, P., Maung-U, K. (eds) Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Adis, Cham. https://doi.org/10.1007/978-3-319-15961-4_13

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  • DOI: https://doi.org/10.1007/978-3-319-15961-4_13

  • Publisher Name: Adis, Cham

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