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Therapeutic Importance of Curcumin in Neurological Disorders Other Than Alzheimer Disease

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Therapeutic Potentials of Curcumin for Alzheimer Disease

Abstract

Curcumin mediates its neuroprotective effects not only in neurotraumatic disorders (stroke, spinal cord injury, traumatic brain injury, and epilepsy), but also in Parkinson disease, Huntington disease, and prion diseases. In addition, curcumin also promote its beneficial effects in neuropsychological disorders (depression, biopolar disorders, and tardive dyskinesia). The mechanism associated with neuroprotective action of curcumin is not fully understood. However, it is becoming increasingly evident that anti-inflammatory and antioxidant properties of curcumin may be responsible for neuroprotective effects. At the molecular level, neuroprotective effects of curcumin are accompanied by downregulating activities of phospholipases, lipooxygenase, cyclooxygenase-2, which lead to low levels of leukotrienes, thromboxanes, prostaglandins. In addition, curcumin also inhibits the expression of TNF-α, IL-12, MCP-1, and interferon-inducible protein. In addition, curcumin also modulates various neurotransmitter levels in the brain.

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  1. Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, 43210, USA

    Akhlaq A. Farooqui

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Farooqui, A.A. (2016). Therapeutic Importance of Curcumin in Neurological Disorders Other Than Alzheimer Disease. In: Therapeutic Potentials of Curcumin for Alzheimer Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-15889-1_8

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