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Effect of Curcumin on Growth Factors and Their Receptors, Ion Channels, and Transporters in the Visceral Organs and the Brain

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Therapeutic Potentials of Curcumin for Alzheimer Disease

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Abstract

Curcumin is a diferulomethane derived from the Indian spice plant Curcuma longa. It interferes with cell signaling pathways associated with apoptotic cell death, proliferation, angiogenesis, neuroinflammation, and oxidative stress. Recent studies have revealed that curcumin mediates its effects by interacting and modulating with several growth factors (VEGF, bFGF, EGF, and HIF), ion channels, and transporters. These growth factors not only regulate inflammatory responses and control apoptotic cell death, but also modulate angiogenesis. Molecular mechanisms of curcumin action not only include the inhibition of proinflammatory enzymes, such as COX-2, LOX, and iNOS, PtdIns 3 K, and tyrosine kinases, but also the activation of MAPK and PKC along with the modulation of several cell survival/cell-cycle genes.

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  1. Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA

    Akhlaq A. Farooqui

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Farooqui, A.A. (2016). Effect of Curcumin on Growth Factors and Their Receptors, Ion Channels, and Transporters in the Visceral Organs and the Brain. In: Therapeutic Potentials of Curcumin for Alzheimer Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-15889-1_5

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