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Metabolism, Bioavailability, Biochemical Effects of Curcumin in Visceral Organs and the Brain

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Therapeutic Potentials of Curcumin for Alzheimer Disease

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Abstract

It is well known that curcumin produces antioxidant, anti-inflammatory, anticancer, antiviral, and antiarthritic properties. The poor bioavailability of curcumin is the major hurdle for its more widespread use in animals and humans. However, complexation and encapsulation of curcumin into liposomes, cyclodextrin, curcumin conjugate with PLGA, complexation with phospholipids, and synthesis of curcumin analogs have made it easy to bypass this problem. New ways of delivering curcumin have resulted in increased absorption and delivery of curcumin to various body tissues including brain. The underlying mechanisms of these effects are diverse and appear to involve the regulation of various molecular targets, including transcription factors (NF-κB and HIF-1), growth factors (vascular endothelial cell growth factor), inflammatory cytokines (TNF-α, IL1, and IL-6), and enzymes (protein kinases (MAPK, Akt, COX-2, and 5-LOX).

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    Akhlaq A. Farooqui

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Farooqui, A.A. (2016). Metabolism, Bioavailability, Biochemical Effects of Curcumin in Visceral Organs and the Brain. In: Therapeutic Potentials of Curcumin for Alzheimer Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-15889-1_3

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