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Pathology of Gastric Cancer

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Gastric Cancer

Abstract

Gastric carcinoma represents a group of heterogeneous diseases from its epidemiology, etiology, clinical presentations, pathologic phenotype, and genotype. Management of individual patients with gastric cancer requires the knowledge of all aspects of the disease. This chapter intends to address issues related to pathogenesis, pathobiology, classification and staging, specific diagnostic challenges, and the pathologic assessment post neoadjuvant therapy of gastric carcinoma. Furthermore, recent advances in molecular classification of gastric cancer have served as a valuable adjunct to clinical and pathologic phenotype of the disease. The combined clinical, pathologic, and genetic effort in understanding the disease will certainly facilitate personalized treatment and ultimately improve survival from gastric cancer.

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Abbreviations

GEJ:

Gastroesophageal junction

EBV:

Epstein–Barr Virus

FAP:

Familial Adenomatous polyposis

HNPCC:

Hereditary nonpolyposis colorectal cancer

MSI:

Microsatellite instability

LGD:

Low-grade dysplasia

HGD:

High-grade dysplasia

WHO:

World Health Association

EGC:

Early Gastric Cancer

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Authors and Affiliations

  1. Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, 10022, New York, NY, USA

    Laura H. Tang MD, PhD

  2. Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, 10022, New York, NY, USA

    Luke V. Selby MD

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  1. Laura H. Tang MD, PhD
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Correspondence to Laura H. Tang MD, PhD .

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Editors and Affiliations

  1. Gastric and Mixed Tumor Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Vivian E. Strong

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Tang, L., Selby, L. (2015). Pathology of Gastric Cancer. In: Strong, V. (eds) Gastric Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-15826-6_4

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