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Diagnosis and Management of Ocular Graft-Versus-Host Disease

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Ocular Surface Disease

Abstract

Ocular graft-versus-host disease is one of the most severe forms of ocular surface disease. Inflammation is clearly the underlying pathophysiologic mechanism that leads to the development and progression of the disease. The cases below highlight the latest diagnostic and management strategies as well as the potential complications of this condition. Autologous serum/plasma tears, along with anti-inflammatory therapy, continue to be the main topical treatment options to help control the symptoms and modulate inflammation. Scleral contact lenses are currently the most effective treatment option, and an effective strategy is to offer this option to patients earlier rather than later in the disease course.

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References

  1. Ogawa Y, et al. International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: proposed diagnostic criteria for chronic GVHD (part I). Sci Rep. 2013;3:3419. PMC. Web. 29 2015

    Article  PubMed  PubMed Central  Google Scholar 

  2. Dastjerdi MH, Hamrah P, Al-Arfaj K, Dana R. Disparate corneal nerve alterations between the two eyes in dry eye patients with asymmetric ocular surface manifestations: in vivo confocal microscopy Study. Invest Ophthalmol Vis Sci. 2008;49(13):5315.

    Google Scholar 

  3. Russo PA, Bouchard CS, Galasso JM. Extended-wear silicone hydrogel soft contact lenses in the management of moderate to severe dry eye signs and symptoms secondary to graft-versus-host disease. Eye Contact Lens. 2007;33:144–7.

    Article  PubMed  Google Scholar 

  4. Shikari H, Antin JH, Dana R. Ocular graft-versus-host disease: a review. Surv Ophthalmol. 2013;58(3):233–51.

    Article  PubMed  Google Scholar 

  5. Lelli GJ Jr, Musch DC, Gupta A, et al. Ophthalmic cyclosporine use in ocular GVHD. Cornea. 2006;25:635–8.

    Article  PubMed  Google Scholar 

  6. Pflugfelder SC. Management and therapy of dry eye disease: report of the Management and Therapy Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5(2):163–78.

    Article  Google Scholar 

  7. Jacobs DS, Rosenthal P. Boston scleral lens prosthetic device for treatment of severe dry eye in chronic graft-versus-host disease. Cornea. 2007;26(10):1195–9.

    Article  PubMed  Google Scholar 

  8. DeLoss KS, et al. PROSE treatment for ocular chronic graft-versus-host disease as a clinical network expands. Eye Contact Lens. 2015;42(4):262–6.

    Article  Google Scholar 

  9. Theodore FH, Ferry AP. Superior limbic keratoconjunctivitis: clinical and pathological correlations. Arch Ophthalmol. 1970;84:481–4.

    Article  CAS  PubMed  Google Scholar 

  10. Yang HY, Fujishima H, Toda I, et al. Lacrimal punctal occlusion for the treatment of superior limbic keratoconjunctivitis. Am J Ophthalmol. 1997;124:80–7.

    Article  CAS  PubMed  Google Scholar 

  11. Sivaraman KR, Jivrajka RV, Soin K, Bouchard CS, Movahedan A, Shorter E, Jain S, Jacobs DS, Djalilian AR. Superior limbic keratoconjunctivitis-like inflammation in patients with chronic graft-versus-host disease. Ocul Surf. 2016;14(3):393–400.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Sandeep Jain MD .

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Soin, K., Djalilian, A.R., Jain, S. (2018). Diagnosis and Management of Ocular Graft-Versus-Host Disease. In: Djalilian, A. (eds) Ocular Surface Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-15823-5_6

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  • DOI: https://doi.org/10.1007/978-3-319-15823-5_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-15822-8

  • Online ISBN: 978-3-319-15823-5

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