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Ocular Surface Reconstruction Using Cultivated Corneal and Oral Mucosal Epithelial Transplantation

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Ocular Surface Disease

Abstract

Cultivated epithelial sheet transplantation is a new surgical modality that involves tissue engineering and regenerative medicine to overcome the difficulties that are often observed in treating patients with severe ocular surface disease. These new therapeutic modalities have been shown to dramatically improve the clinical outcomes and prevent sight-threatening complications. Although strict follow-up and precise medical care are both essential for achieving a successful long-term outcome, understanding the specific characteristics of these surgical procedures and their associated complications is likewise crucial for avoiding complications that result in failure of the reconstructed ocular surface and, ultimately, loss of vision. This chapter specifically covers the indications and management strategies for using cultivated limbal epithelial transplantation (CLET) and cultivated oral mucosa epithelial transplantation (COMET) in patients with severe ocular surface disease. It highlights the challenges and the experiences we have gained at Kyoto Prefectural University over the last two decades.

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Authors and Affiliations

  1. Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Tsutomu Inatomi MD, PhD, Takahiro Nakamura MD, PhD, Noriko Koizumi MD, PhD & Chie Sotozono MD, PhD

  2. Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan

    Noriko Koizumi MD, PhD

  3. Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Shigeru Kinoshita MD, PhD

Authors
  1. Tsutomu Inatomi MD, PhD
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  2. Takahiro Nakamura MD, PhD
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  3. Noriko Koizumi MD, PhD
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  4. Chie Sotozono MD, PhD
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  5. Shigeru Kinoshita MD, PhD
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Corresponding author

Correspondence to Tsutomu Inatomi MD, PhD .

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Editors and Affiliations

  1. Cornea Service, Illinois Eye and Ear Infirmary, Chicago, Illinois, USA

    Ali R. Djalilian

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Inatomi, T., Nakamura, T., Koizumi, N., Sotozono, C., Kinoshita, S. (2018). Ocular Surface Reconstruction Using Cultivated Corneal and Oral Mucosal Epithelial Transplantation. In: Djalilian, A. (eds) Ocular Surface Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-15823-5_23

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  • DOI: https://doi.org/10.1007/978-3-319-15823-5_23

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-15822-8

  • Online ISBN: 978-3-319-15823-5

  • eBook Packages: MedicineMedicine (R0)

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