Abstract
Fibromyalgia (FM) is defined as a chronic widespread pain associated with fatigue, insomnia, stiffness, irritable bowel syndrome, and symptoms of anxiety and depression. It is seen in 2–4 % of the general population, with incidence higher among females than males (3.4 vs. 0.5 %). It is estimated to cost approximately US$ 2274 in the annual health-care service utilization for each individual FM patient. The pathogenesis of FM likely involves central sensitization leading to hyperalgesia and allodynia with attenuation of the descending inhibitory pathways. The diagnostic criteria have changed since the American College of Rheumatology (ACR) developed criteria in 1990. These original criteria included widespread pain for at least 3 months and tenderness to palpation in 11 of 18 specified tender points.
These broad criteria lead to confusion in diagnosing FM. A more rigorous definition for FM was developed by the ACR in 2010, and was further modified in 2011. Two key measures—the widespread pain index (WPI) and severity scale (SS)—are utilized in the new system. Evaluation includes pain assessment by way of a detailed history and physical examination including a neurological examination, sleep evaluation, and laboratory workup to rule out other disease states that may mimic FM. Diagnosis requires the presence of chronic widespread pain for at least 3 months, excess tenderness of soft tissues, absence of other conditions that may explain symptoms, and other associated clinical features. This chapter is focused on the diagnosis and evaluation of patients with FM.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum. 1995;38(1):19–28. PubMed PMID: 7818567.
Wolfe F, Anderson J, Harkness D, Bennett RM, Caro XJ, Goldenberg DL, et al. A prospective, longitudinal, multicenter study of service utilization and costs in fibromyalgia. Arthritis Rheum. 1997;40(9):1560–70. PubMed PMID: 9324009.
Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, et al.; National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008;58(1):26–35. doi:10.1002/art.23176. PubMed PMID:18163497; PubMed Central PMCID: PMC3266664.
White KP, Speechley M, Harth M, Ostbye T. The London fibromyalgia epidemiology study: the prevalence of fibromyalgia syndrome in London, Ontario. J Rheumatol. 1999;26(7):1570–6. PubMed PMID:10405947.
Sarzi-Puttini P, Atzeni F, Mease PJ. Chronic widespread pain: from peripheral to central evolution. Best Pract Res Clin Rheumatol. 2011;25(2):133–9. doi:10.1016/j.berh.2011.04.001. Review. PubMed PMID:22094190.
Petzke F, Clauw DJ, Ambrose K, Khine A, Gracely RH. Increased pain sensitivity in fibromyalgia: effects of stimulus type and mode of presentation. Pain. 2003;105(3):403–13. PubMed PMID:14527701.
Geisser ME, Glass JM, Rajcevska LD, Clauw DJ, Williams DA, Kileny PR, et al. A psychophysical study of auditory and pressure sensitivity in patients with fibromyalgia and healthy controls. J Pain. 2008;9(5):417–22. doi:10.1016/j.jpain.2007.12.006. Epub 2008 Feb 15. PubMed PMID:18280211.
Nebel MB, Gracely RH. Neuroimaging of fibromyalgia. Rheum Dis Clin North Am. 2009;35(2):313–27. doi:10.1016/j.rdc.2009.06.004. Review. PubMed PMID:19647145.
Schmidt-Wilcke T, Clauw DJ. Fibromyalgia: from pathophysiology to therapy. Nat Rev Rheumatol. 2011;7(9):518–27. doi:10.1038/nrrheum.2011.98. Review. PubMed PMID:21769128.
Russell IJ, Vaeroy H, Javors M, Nyberg F. Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis. Arthritis Rheum. 1992;35(5):550–6. PubMed PMID:1374252.
Giovengo SL, Russell IJ, Larson AA. Increased concentrations of nerve growth factor in cerebrospinal fluid of patients with fibromyalgia. J Rheumatol. 1999;26(7):1564–9. PubMed PMID:10405946.
Gürsoy S, Erdal E, Herken H, Madenci E, Alaşehirli B, Erdal N. Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome. Rheumatol Int. 2003;23(3):104–7. Epub 2002 Oct 22. PubMed PMID:12739038.
Harris RE, Clauw DJ, Scott DJ, McLean SA, Gracely RH, Zubieta JK. Decreased central mu-opioid receptor availability in fibromyalgia. J Neurosci. 2007;27(37):10000–6. PubMed PMID:17855614.
Smythe HA, Moldofsky H. Two contributions to understanding of the “fibrositis” syndrome. Bull Rheum Dis. 1977–1978;28(1):928–31. PubMed PMID:199304.
Yunus M, Masi AT, Calabro JJ, Miller KA, Feigenbaum SL. Primary fibromyalgia (fibrositis): clinical study of 50 patients with matched normal controls. Semin Arthritis Rheum. 1981;11(1):151–71. PubMed PMID:6944796.
Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33(2):160–72. PubMed PMID:2306288
Fitzcharles MA, Boulos P. Inaccuracy in the diagnosis of fibromyalgia syndrome: analysis of referrals. Rheumatology (Oxford). 2003;42(2):263–7. PubMed PMID:12595620.
Bennett RM. Clinical manifestations and diagnosis of fibromyalgia. Rheum Dis Clin North Am. 2009;35(2):215–32. doi:10.1016/j.rdc.2009.05.009. Review. PubMed PMID:19647138.
Goldenberg DL. Diagnosis and differential diagnosis of fibromyalgia. Am J Med. 2009;122(12 Suppl):S14–21. doi:10.1016/j.amjmed.2009.09.007. PubMed PMID:19962492.
Mease P. Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatment. J Rheumatol Suppl. 2005;75:6–21. Review. Erratum in: J Rheumatol Suppl. 2005 Oct;32(10):2063. PubMed PMID:16078356.
Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken). 2010;62(5):600–10. doi:10.1002/acr.20140. PubMed PMID:20461783.
Yunus MB. Symptoms and signs of fibromyalgia syndrome: an over- view. In: Wallace DJ, Clauw DJ, editors. Fibromyalgia & other central pain syndromes. New York: Lippincott Williams & Wilkins; 2005. p. 125–32.
Goldenberg DL, Burckhardt C, Crofford L. Management of fibromyalgia syndrome. JAMA. 2004;292(19):2388–95. Review. PubMed PMID:15547167.
Aaron LA, Buchwald D. A review of the evidence for overlap among unexplained clinical conditions. Ann Intern Med. 2001;134(9 Pt 2):868–81. Review. PubMed PMID:11346323.
Goldenberg DL. Fibromyalgia and related syndromes. In: Klippel JH, Dieppe PA, Arnett FC, et al. editors. Rheumatology. 2nd ed. St. Louis: Mosby; 1998. p. 15.1–15.12.
Ohayon MM. Prevalence and correlates of nonrestorative sleep complaints. Arch Intern Med. 2005;165(1):35–41. PubMed PMID:15642872.
Mahowald MW. Restless leg syndrome and periodic limb movements of sleep. Curr Treat Options Neurol. 2003;5(3):251–60. PubMed PMID:12670414.
Fietta P, Fietta P, Manganelli P. Fibromyalgia and psychiatric disorders. Acta Biomed. 2007;78(2):88–95. Review. PubMed PMID:17933276.
Arnold LM, Crofford LJ, Martin SA, Young JP, Sharma U. The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgia. Pain Med. 2007;8(8):633–8. PubMed PMID:18028041.
Boyer AL, Mira Pastor MA, Calatayud NP, Lopez-Roig S, Cantero Terol MC. Comparing fibromyalgia patients from primary care and rheumatology settings: clinical and psychosocial features. Rheumatol Int. 2009;29(10):1151–60. doi:10.1007/s00296-008-0818-y. Epub 2008 Dec 19. PubMed PMID:19096850.
Raphael KG, Widom CS, Lange G. Childhood victimization and pain in adulthood: a prospective investigation. Pain. 2001;92(1–2):283–93. PubMed PMID:11323150.
Hart-Johnson T, Green CR. The impact of sexual or physical abuse history on pain-related outcomes among blacks and whites with chronic pain: gender influence. Pain Med. 2012;13(2):229–42. doi:10.1111/j.1526-4637.2011.01312.x. Epub 2012 Feb 1. PubMed PMID:22296712.
Bennett RM, Jones J, Turk DC, Russell IJ, Matallana L. An internet survey of 2,596 people with fibromyalgia. BMC Musculoskelet Disord. 2007;8:27. PubMed PMID:17349056; PubMed Central PMCID:PMC1829161.
McHugh MP, Connolly DA, Eston RG, Kremenic IJ, Nicholas SJ, Gleim GW. The role of passive muscle stiffness in symptoms of exercise-induced muscle damage. Am J Sports Med. 1999;27(5):594–9. PubMed PMID:10496575.
Park DC, Glass JM, Minear M, Crofford LJ. Cognitive function in fibromyalgia patients. Arthritis Rheum. 2001;44(9):2125–33. PubMed PMID:11592377.
Yunus MB. Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness. Semin Arthritis Rheum. 2008;37(6):339–52. doi:10.1016/j.semarthrit.2007.09.003. Epub 2008 Jan 14. PubMed PMID:18191990.
Wallace DJ. Genitourinary manifestations of fibrositis: an increased association with the female urethral syndrome. J Rheumatol. 1990;17(2):238–9. PubMed PMID:2319522.
Clauw DJ, Schmidt M, Radulovic D, Singer A, Katz P, Bresette J. The relationship between fibromyalgia and interstitial cystitis. J Psychiatr Res. 1997;31(1):125–31. PubMed PMID:9201654.
Fitzcharles MA, Boulos P. Inaccuracy in the diagnosis of fibromyalgia syndrome: analysis of referrals. Rheumatology (Oxford). 2003;42(2):263–7. PubMed PMID:12595620.
Burckhardt CS, Goldenberg D, Crofford L. Guideline for the management of fibromyalgia syndrome pain in adults and children. APS Clinical Practice Guideline Series, No. 4. Glenview: American Pain Society. 2005.
Clauw DJ, Crofford LJ. Chronic widespread pain and fibromyalgia: what we know, and what we need to know. Best Pract Res Clin Rheumatol. 2003;17(4):685–701. Review. PubMed PMID:12849719.
Daoud KF, Barkhuizen A. Rheumatic mimics and selected triggers of fibromyalgia. Curr Pain Headache Rep. 2002;6(4):284–8. Review. PubMed PMID:12095463.
Steere AC, Taylor E, McHugh GL, Logigian EL. The overdiagnosis of Lyme disease. JAMA. 1993;269(14):1812–6. PubMed PMID:8459513.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Henriquez, O., Peck, D. (2015). Fibromyalgia Diagnosis. In: Lawson, MD, E., Wallace, MD, M. (eds) Fibromyalgia. Springer, Cham. https://doi.org/10.1007/978-3-319-15820-4_2
Download citation
DOI: https://doi.org/10.1007/978-3-319-15820-4_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-15819-8
Online ISBN: 978-3-319-15820-4
eBook Packages: MedicineMedicine (R0)