Segmentation and 3D Reconstruction of Animal Tissues in Histological Images

  • Liliana Azevedo
  • Augusto M. R. Faustino
  • João Manuel R. S. Tavares
Conference paper
Part of the Lecture Notes in Computational Vision and Biomechanics book series (LNCVB, volume 21)


Histology is considered the “gold standard” to access anatomical information at a cellular level. In histological studies, tissue samples are cut into very thin sections, stained, and observed under a microscope by a specialist. Such studies, mainly concerning tissue structures, cellular components and their interactions, can be useful to detect and diagnose certain pathologies. Thus, to find new techniques and computational solutions to assist this diagnosis, such as the 3D image based tissue reconstruction, is extremely interesting. In this chapter, a methodology to build 3D models from histological images is proposed, and the results obtained using this methodology in four experimental cases are presented and discussed based on quantitative and qualitative metrics.


Histology Image analysis Image segmentation Image registration 



This work was partially done in the scope of the project with reference PTDC/BBB-BMD/3088/2012, financially supported by Fundação para a Ciência e a Tecnologia (FCT), in Portugal.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Liliana Azevedo
    • 1
  • Augusto M. R. Faustino
    • 2
  • João Manuel R. S. Tavares
    • 1
  1. 1.Instituto de Engenharia Mecânica e Engenharia Industrial, Faculdade de EngenhariaUniversidade do PortoPortoPortugal
  2. 2.Instituto de Ciências Biomédicas Abel SalazarUniversidade do PortoPortoPortugal

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