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The Role of p110δ in the Development and Activation of B Lymphocytes

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Crossroads Between Innate and Adaptive Immunity V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 850))

Abstract

The phosphatidylinositol-3-kinase (PI3K) pathway has an essential role in signal transduction, where it is required for a number of different cellular processes including proliferation, differentiation, development, migration and growth. In the immune system, PI3K regulates inflammation by controlling the activation and recruitment of leukocytes. The generation of conditional knockout mice has allowed the study of PI3K isoforms specifically in B and T lymphocytes, and demonstrates the importance of intact signalling in their development and function. PI3K signalling must be tightly regulated in lymphocytes as excessive PI3K can lead to autoimmunity, immunodeficiency or cancer, whilst diminished signalling can result in developmental defects and immunodeficiency. Recent advances in the understanding of PI3K signalling have hastened the application of isoform-specific PI3K inhibitors, which are currently undergoing clinical trials. This review will focus on the p110δ catalytic subunit of the class 1A family of PI3K, and its role in the development and activation of B lymphocytes through various downstream effectors.

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Acknowledgements

Work in the authors’ laboratory is funded by the Biotechnology and Biological Sciences Research Council. R. N is supported by a CASE studentship in partnership with GSK.

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  1. Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, CB22 3AT, Babraham, UK

    Rebecca Newman & Martin Turner

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  1. Rebecca Newman
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Correspondence to Rebecca Newman .

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  1. Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, La Jolla, USA

    Stephen P. Schoenberger

  2. Department Microbiology & Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Peter D. Katsikis

  3. Yerkes National Primate Research Center, Emory University Emory Vaccine Center &, Atlanta, Georgia, USA

    Bali Pulendran

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Newman, R., Turner, M. (2015). The Role of p110δ in the Development and Activation of B Lymphocytes. In: Schoenberger, S., Katsikis, P., Pulendran, B. (eds) Crossroads Between Innate and Adaptive Immunity V. Advances in Experimental Medicine and Biology, vol 850. Springer, Cham. https://doi.org/10.1007/978-3-319-15774-0_9

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