Induction of Immune Tolerance to Dietary Antigens

  • Kwang Soon Kim
  • Charles D. SurhEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 850)


The intestinal immune system is continuously exposed to massive amounts of diverse antigens derived from both food and intestinal microbes. Immunological tolerance to these enteric antigens is critical for ensuring intestinal and systemic immune homeostasis. Oral tolerance is a specific type of peripheral tolerance induced by the exposure of antigen via the oral route, emphasizing the role of intestinal immune system for preventing unnecessary hypersensitivity reactions to innocuous dietary and microbial antigens. Here, we discuss how dietary antigens are recognized by intestinal immune systems and highlight the role of Foxp3+ regulatory CD4+ T cells (Tregs) in establishment of oral tolerance, the tolerogenic features of intestinal dendritic cells that induce development of Foxp3+ Tregs, and the factors that promote development of the intestinal dendritic cells.


Intestinal immune system Gut-associated lymphoid tissues (GALT) Dietary antigens Foxp3+ regulatory CD4+ T cells Intestinal dendritic cells 



We thank Drs. Sung Wook Hong and Yun Ji Park for commenting on the manuscript and creating illustrative figures. This work was supported by Institute for Basic Science (IBS).


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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Academy of Immunology and Microbiology (AIM)Institute for Basic Science (IBS)PohangRepublic of Korea
  2. 2.Department of Integrative Biosciences and BiotechnologyPohang University of Science and Technology (POSTECH)PohangRepublic of Korea
  3. 3.Division of Developmental ImmunologyLa Jolla institute for Allergy and ImmunologyLa JollaUSA

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