Skip to main content

Fluorescence Imaging Systems (PDE, HyperEye Medical System, and Prototypes in Japan)

  • Chapter
Fluorescence Imaging for Surgeons

Abstract

Clinical application of fluorescence-guided surgery using indocyanine green has been expanded with the advances in imaging techniques and distribution of fluorescence imaging systems on the market. We describe the history of the development and characteristics of fluorescence imaging systems for clinical use that are currently available in Japan: PDE®, HyperEye Medical System, and other prototype laparoscopic imaging systems.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ishizawa T, Kokudo N. The beginning of a new era of digestive surgery guided by fluorescence imaging. Liver Cancer. 2014;3:6.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Aoki T, Yasuda D, Shimizu Y, Odaira M, Niiya T, Kusano T, et al. Image-guided liver mapping using fluorescence navigation system with indocyanine green for anatomical hepatic resection. World J Surg. 2008;32:1763–7.

    Article  PubMed  Google Scholar 

  3. Mitsuhashi N, Kimura F, Shimizu H, Imamaki M, Yoshidome H, Ohtsuka M, et al. Usefulness of intraoperative fluorescence imaging to evaluate local anatomy in hepatobiliary surgery. J Hepatobiliary Pancreat Surg. 2008;15:508–14.

    Article  PubMed  Google Scholar 

  4. Ishizawa T, Tamura S, Masuda K, Aoki T, Hasegawa K, Imamura H, et al. Intraoperative fluorescent cholangiography using indocyanine green: a biliary road map for safe surgery. J Am Coll Surg. 2008;208:e1–4.

    Article  PubMed  Google Scholar 

  5. Ishizawa T, Fukushima N, Shibahara J, Masuda K, Tamura S, Aoki T, et al. Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer. 2009;115:2491–504.

    Article  PubMed  Google Scholar 

  6. Gotoh K, Yamada T, Ishikawa O, Takahashi H, Eguchi H, Yano M, et al. A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation. J Surg Oncol. 2009;100:75–9.

    Article  PubMed  Google Scholar 

  7. Hirono S, Tani M, Kawai M, Okada K, Miyazawa M, Shimizu A, et al. Identification of the lymphatic drainage pathways from the pancreatic head guided by indocyanine green fluorescence imaging during pancreaticoduodenectomy. Dig Surg. 2012;29:132–9.

    Article  PubMed  Google Scholar 

  8. Mihara M, Murai N, Hayashi Y, Hara H, Iida T, Narushima M, et al. Using indocyanine green fluorescent lymphography and lymphatic-venous anastomosis for cancer-related lymphedema. Ann Vasc Surg. 2012;278:e1–6.

    Google Scholar 

  9. Handa T, Katare RG, Nishimori H, Wariishi S, Fukutomi T, Yamamoto M, et al. New device for intraoperative graft assessment: HyperEye charge-coupled device camera system. Gen Thorac Cardiovasc Surg. 2010;58:68–77.

    Article  PubMed  Google Scholar 

  10. Yamauchi K, Nagafuji H, Nakamura T, Sato T, Kohno N. Feasibility of ICG fluorescence-guided sentinel node biopsy in animal models using the HyperEye Medical System. Ann Surg Oncol. 2011;18:2042–7.

    Article  PubMed  Google Scholar 

  11. Kawaguchi Y, Ishizawa T, Masuda K, Sato S, Kaneko J, Aoki T, et al. Hepatobiliary surgery guided by a novel fluorescent imaging technique for visualizing hepatic arteries, bile ducts, and liver cancers on color images. J Am Coll Surg. 2011;212:e33–9.

    Article  PubMed  Google Scholar 

  12. Nimura H, Narimiya N, Mitsumori N, Yamazaki Y, Yanaga K, Urashima M. Infrared ray electronic endoscopy combined with indocyanine green injection for detection of sentinel nodes of patients with gastric cancer. Br J Surg. 2004;91:575–9.

    Article  CAS  PubMed  Google Scholar 

  13. Kusano M, Tajima Y, Yamazaki K, Kato M, Watanabe M, Miwa M. Sentinel node mapping guided by indocyanine green fluorescence imaging: a new method for sentinel node navigation surgery in gastrointestinal cancer. Dig Surg. 2008;25:103–8.

    Article  PubMed  Google Scholar 

  14. Harada K, Miwa M, Fukuyo T, Watanabe S, Enosawa S, Chiba T. ICG fluorescence endoscope for visualization of the placental vascular network. Minim Invasive Ther Allied Technol. 2009;18:1–5.

    Article  PubMed  Google Scholar 

  15. Ishizawa T, Bandai Y, Ijichi M, Kaneko J, Hasegawa K, Kokudo N. Fluorescent cholangiography illuminating the biliary tree during laparoscopic cholecystectomy. Br J Surg. 2010;97:1369–77.

    Article  CAS  PubMed  Google Scholar 

  16. Kudo H, Ishizawa T, Tani K, Harada N, Ichida A, Shimizu A, et al. Application of indocyanine-green fluorescence imaging for visualizing hepatic malignancy during laparoscopic surgery. Surg Endosc. 2014;28:2504.

    Article  PubMed  Google Scholar 

  17. Ishizawa T, Zuker NB, Kokudo N, Gayet B. Positive and negative staining of hepatic segments by use of fluorescent imaging techniques during laparoscopic hepatectomy. Arch Surg. 2012;147:393–4.

    Article  PubMed  Google Scholar 

Download references

Financial Disclosure: The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in this manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, and royalties. No writing assistance was used in the production of this manuscript.

Funding/Support: This work was supported by grants from the Takeda Science Foundation, the Ministry of Education, Culture, Sports, Science, Technology of Japan, and the Ministry of Health, Labour, and Welfare of Japan, and Global Leader Program for Social Design and Management.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Norihiro Kokudo M.D., Ph.D. .

Editor information

Editors and Affiliations

Electronic Supplementary Material

Below is the link to the electronic supplementary material.

Identification of primary and secondary liver cancer during hepatectomy by the series of PDE® systems (WMV 76,462 kb)

Intraoperative real-time identification of disseminated nodules caused by percutaneous radiofrequency ablation for hepatocellular carcinoma using the HyperEye Medical System (WMV 63,227 kb)

Fluorescence cholangiography using the HyperEye Medical System during donor right hepatectomy (WMV 61,351 kb)

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Ishizawa, T., Kokudo, N. (2015). Fluorescence Imaging Systems (PDE, HyperEye Medical System, and Prototypes in Japan). In: Dip, F., Ishizawa, T., Kokudo, N., Rosenthal, R. (eds) Fluorescence Imaging for Surgeons. Springer, Cham. https://doi.org/10.1007/978-3-319-15678-1_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-15678-1_7

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-15677-4

  • Online ISBN: 978-3-319-15678-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics