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The Indocyanine Green Method Is Equivalent to the (99m) Tc-Labeled Radiotracer Method for Identifying the Sentinel Node in Breast Cancer: A Concordance and Validation Study

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Fluorescence Imaging for Surgeons

Abstract

We assessed concordance between the indocyanine green (ICG) method and 99mTc-radiotracer method to identify the sentinel node (SN). One hundred thirty-four women with clinically node-negative early breast cancer received preoperative injection of 99mTc-labeled tracer for lymphoscintigraphy, followed by intraoperative injection of ICG for detection of SNs. The 134 patients provided 246 SNs, detected by one or both methods. The two methods were concordant for 230/246 (93.5 %) SNs and discordant for 16 (6.5 %) SNs. The ICG method detected 99.6 % of all SNs. Fluorescent lymphangiography with ICG allows an easy identification of axillary SNs, at a frequency not inferior to that of the radiotracer method and can be used alone to reliably identify SNs.

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Authors and Affiliations

  1. Division of Senology, European Institute of Oncology, Via G. Ripamonti, 435, Milan, 20141, Italy

    Bettina Ballardini M.D., Germana Lissidini M.D. & Paolo Veronesi M.D.

Authors
  1. Bettina Ballardini M.D.
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  2. Germana Lissidini M.D.
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  3. Paolo Veronesi M.D.
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Correspondence to Bettina Ballardini M.D. .

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Editors and Affiliations

  1. Section of Minimally Invasive Surgery, Department of General and Vascular Surgery, The Bariatric and Metabolic Institute, Cleveland Clinic Florida, FL, USA; Oncological Surgical Division, Division of Surgical Research, Department of Surgery, Hospital de Clinicas Buenos Aires, University of Buenos Aires, Buenos Aires, Argentina

    Fernando D. Dip

  2. Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research; Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

    Takeaki Ishizawa

  3. Hepato-Biliary-Pancreatic Surgery; Department of Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

    Norihiro Kokudo

  4. Department of General Surgery, Section of Minimally Invasive Surgery; Department of General and Vascular Surgery, The Bariatric and Metabolic Institute, Cleveland Clinic Florida, Weston, Florida, USA

    Raul J. Rosenthal

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Ballardini, B., Lissidini, G., Veronesi, P. (2015). The Indocyanine Green Method Is Equivalent to the (99m) Tc-Labeled Radiotracer Method for Identifying the Sentinel Node in Breast Cancer: A Concordance and Validation Study. In: Dip, F., Ishizawa, T., Kokudo, N., Rosenthal, R. (eds) Fluorescence Imaging for Surgeons. Springer, Cham. https://doi.org/10.1007/978-3-319-15678-1_27

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  • DOI: https://doi.org/10.1007/978-3-319-15678-1_27

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