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Development of a Non-blurring, Dual-Imaging (X-Ray/Fluorescence) Tissue Marker for Localization of Gastrointestinal Tumors

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Fluorescence Imaging for Surgeons

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Abstract

Non-blurring tissue marker detectable by both X-ray computed tomography (CT) and near-infrared fluorescence laparoscope (NIR-FL) was newly developed to localize gastrointestinal tumors both preoperatively and intraoperatively, and its usefulness was examined with an animal model. Hydrophobic NIR fluorophore and ethiodized oil were aggregated with polyglycerol polyricinoleate into polymersome. This aggregate of 300 ml was administered into the porcine stomach using gastroendoscope, and CT and NIR-FL were performed. Four injection points within a 1-cm radius were individually identified with both modalities immediately and 18 h after administration. This dual-imaging marker could contribute to both preoperative simulation and intraoperative navigation for laparoscopic gastrointestinal surgery.

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Author information

Authors and Affiliations

  1. Center for Frontier Medical Engineering, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan

    Hideki Hayashi M.D., Ph.D.

  2. Department of Basic Science, University of Tokyo, Komaba, Tokyo, Japan

    Taro Toyota Ph.D.

  3. Faculty of Engineering, Chiba University, Chiba, Japan

    Shoichi Goto B.A. & Aki Oishi

  4. Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan

    Tao Gao M.S. & Hisahiro Matsubara M.D., Ph.D.

  5. Graduate School of Engineering,, Chiba University, Chiba, Japan

    Lau Bik Ee B.A.

Authors
  1. Hideki Hayashi M.D., Ph.D.
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  2. Taro Toyota Ph.D.
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  3. Shoichi Goto B.A.
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  4. Aki Oishi
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  5. Tao Gao M.S.
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  6. Lau Bik Ee B.A.
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  7. Hisahiro Matsubara M.D., Ph.D.
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Corresponding author

Correspondence to Hideki Hayashi M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Section of Minimally Invasive Surgery, Department of General and Vascular Surgery, The Bariatric and Metabolic Institute, Cleveland Clinic Florida, FL, USA; Oncological Surgical Division, Division of Surgical Research, Department of Surgery, Hospital de Clinicas Buenos Aires, University of Buenos Aires, Buenos Aires, Argentina

    Fernando D. Dip

  2. Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research; Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

    Takeaki Ishizawa

  3. Hepato-Biliary-Pancreatic Surgery; Department of Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan

    Norihiro Kokudo

  4. Department of General Surgery, Section of Minimally Invasive Surgery; Department of General and Vascular Surgery, The Bariatric and Metabolic Institute, Cleveland Clinic Florida, Weston, Florida, USA

    Raul J. Rosenthal

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© 2015 Springer International Publishing Switzerland

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Hayashi, H. et al. (2015). Development of a Non-blurring, Dual-Imaging (X-Ray/Fluorescence) Tissue Marker for Localization of Gastrointestinal Tumors. In: Dip, F., Ishizawa, T., Kokudo, N., Rosenthal, R. (eds) Fluorescence Imaging for Surgeons. Springer, Cham. https://doi.org/10.1007/978-3-319-15678-1_23

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  • DOI: https://doi.org/10.1007/978-3-319-15678-1_23

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-15677-4

  • Online ISBN: 978-3-319-15678-1

  • eBook Packages: MedicineMedicine (R0)

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