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Animal Models of Tension-Type Headache and Trigeminal Autonomic Cephalalgias

  • Chapter
Pathophysiology of Headaches

Part of the book series: Headache ((HEAD))

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Abstract

Primary headaches represent a common and major health problem worldwide and significantly impair patients’ quality of life; however, pathophysiological mechanisms remain obscure. While migraine is the most studied of the primary headaches, several others also exist that are differentiated from migraine by their characteristic symptomatology and pathophysiology. These include tension-type headache and the trigeminal autonomic cephalalgias, such as cluster headache. Several animal models have provided a translational knowledge on migraine pathophysiology; however, animal models for studies of other primary headaches, such as tension-type headache and cluster headache, evaluating their underlying pathophysiology are very limited. In this chapter, we will briefly review the known putative mechanisms of some of the other primary headaches and the current animal models for these headache types that are used to aid our understanding of their pathophysiology.

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Authors and Affiliations

  1. Laboratory of Neurophysiology of Integrative Autonomic Systems, Headache Science Centre, National Neurological Institute C. Mondino, Via Mondino 2, Pavia, 27100, Italy

    Cristina Tassorelli MD, PhD & Rosaria Greco PhD

  2. Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy

    Cristina Tassorelli MD, PhD

  3. Department of Oral and Maxillofacial Pathology, Radiology and Medicine, New York University College of Dentistry, 345 East 24th Street, New York, NY, 10010, USA

    Simon Akerman PhD

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  1. Cristina Tassorelli MD, PhD
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  2. Rosaria Greco PhD
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  3. Simon Akerman PhD
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Correspondence to Cristina Tassorelli MD, PhD or Simon Akerman PhD .

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Editors and Affiliations

  1. Department of Neurology, Danish Headache Center Rigshospitalet and Glostrup Hospital, Glostrup, Denmark

    Messoud Ashina

  2. Department of Health Sciences, University of Florence, Florence, Italy

    Pierangelo Geppetti

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Tassorelli, C., Greco, R., Akerman, S. (2015). Animal Models of Tension-Type Headache and Trigeminal Autonomic Cephalalgias. In: Ashina, M., Geppetti, P. (eds) Pathophysiology of Headaches. Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-15621-7_3

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  • DOI: https://doi.org/10.1007/978-3-319-15621-7_3

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  • Print ISBN: 978-3-319-15620-0

  • Online ISBN: 978-3-319-15621-7

  • eBook Packages: MedicineMedicine (R0)

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