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Anatomy of Headache

  • Chapter
Pathophysiology of Headaches

Part of the book series: Headache ((HEAD))

Abstract

Clinical human and experimental animal studies have facilitated our understanding of the essential structures in the initiation, transmission, modulation, and maintenance of headache. Pain-sensitive cranial structures, such as the dura mater encephali and large intracerebral blood vessels, and the cranial and cervical muscles and ligaments, which are innervated by primary afferent neurons originating from the trigeminal ganglia, take pivotal role in headache generation. Nociceptive impulses originated in the peripheral structures are then transmitted to central structures via second-order trigeminal neurons in the trigeminocervical complex in the brainstem. In addition to bottom organization of headache, top-down modulation of nociceptive stimuli from cranial structures through descending pathways is also discussed in this chapter.

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Authors and Affiliations

  1. Department of Neurology and Algology, Neuropsychiatry Centre, Gazi University, Beşevler, Ankara, 06510, Turkey

    Hayrunnisa Bolay MD, PhD & Didem Akcali MD, PhD

  2. Institute of Physiology and Pathophysiology, University of Erlangen-Nürnberg, Universitätsstr. 17, Erlangen, D-91054, Germany

    Karl Messlinger

  3. Department of Physiology, University of Szeged, Dóm tér 10., Szeged, H-6720, Hungary

    Mária Dux

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  1. Hayrunnisa Bolay MD, PhD
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  2. Karl Messlinger
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  3. Mária Dux
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  4. Didem Akcali MD, PhD
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Correspondence to Hayrunnisa Bolay MD, PhD or Karl Messlinger .

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  1. Department of Neurology, Danish Headache Center Rigshospitalet and Glostrup Hospital, Glostrup, Denmark

    Messoud Ashina

  2. Department of Health Sciences, University of Florence, Florence, Italy

    Pierangelo Geppetti

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Bolay, H., Messlinger, K., Dux, M., Akcali, D. (2015). Anatomy of Headache. In: Ashina, M., Geppetti, P. (eds) Pathophysiology of Headaches. Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-15621-7_1

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