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Oxidative Stress in Acute Liver Failure

  • Chapter
Studies on Hepatic Disorders

Abstract

Acute liver failure (ALF) is a rapid-onset condition that is characterized by coagulopathy and encephalopathy. Although rare, mortality is high and liver transplantation is often the only available cure. ALF is not itself a liver disease, but is a severe outcome of several forms of acute liver injury. Importantly, it has been suggested that oxidative stress has a role in the mechanisms of liver injury in several of these etiologies. This is especially true in acetaminophen hepatotoxicity and viral hepatitis, for which there is clear evidence that mitochondrial oxidative stress is important in the pathophysiology. Interestingly, although oxidative stress is generally considered detrimental in liver disease, it has recently been shown to promote liver regeneration in some preclinical models. This may open new avenues of exploration for future research. A better understanding of the role of oxidative stress in liver injury and repair may lead to the development of new therapeutic interventions to combat ALF.

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Authors and Affiliations

  1. Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS, 66160, USA

    Mitchell R. McGill Ph.D. & Hartmut Jaeschke Ph.D.

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  1. Mitchell R. McGill Ph.D.
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  2. Hartmut Jaeschke Ph.D.
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Correspondence to Mitchell R. McGill Ph.D. .

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Editors and Affiliations

  1. Department of Health Sciences, University of Eastern Piedmont Amedeo Avogadro, Novara, Italy

    Emanuele Albano

  2. Department of Clinical and Biological Sciences, Unit of Experimental Medicine and Clinical Pathology, School of Medicine, University of Torino, Torino, Italy

    Maurizio Parola

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McGill, M.R., Jaeschke, H. (2015). Oxidative Stress in Acute Liver Failure. In: Albano, E., Parola, M. (eds) Studies on Hepatic Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Cham. https://doi.org/10.1007/978-3-319-15539-5_9

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