Skip to main content
SpringerLink
Log in

Oxidative Stress and Liver Transplantation

  • Chapter
Studies on Hepatic Disorders

  • 970 Accesses

Abstract

The risk of oxidative stress in liver transplant population is multifactorial and results mainly from preexisting liver issues, ischemia–reperfusion injury, immunosuppressive regimens, and posttransplant complications. Generation of reactive oxygen species may be increased in marginal grafts, which are used more frequently so as to extend the donor pool. Consequences of prolonged oxidative imbalance remain unclear, however its importance is well recognized in atherosclerosis and cardiovascular complications which are important cause of morbidity and mortality with increasing rates. In this chapter we focused on the risk of oxidative stress complications in liver transplant population and possible ways of effective approach.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Czubkowski P, Socha P, Pawlowska J (2010) Current status of oxidative stress in pediatric liver transplantation. Pediatr Transplant 14:169–177

    CAS  PubMed  Google Scholar 

  2. Jaeschke H, Woolbright BL (2012) Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species. Transplant Rev 26:103–114

    Google Scholar 

  3. Nastos C, Kalimeris K, Papoutsidakis N, Tasoulis MK, Lykoudis PM, Theodoraki K, Nastou D, Smyrniotis V, Arkadopoulos N (2014) Global consequences of liver ischemia/reperfusion injury. Oxid Med Cell Longev 2014:1–13

    Google Scholar 

  4. Augusto VS, Rodrigues AJ, Reis GS, Silveira APC, de Castro E, Silva O Jr, Mente ED, Jordão AA Jr, Evora PR (2014) Evaluation of oxidative stress in the late postoperative stage of liver transplantation. Transplant Proc 46:1453–1457

    CAS  PubMed  Google Scholar 

  5. Trevisani F, Caraceni P, Simoncini M, Micati M, Domenicali M, Dazzani F, Zambruni A, Stefanelli C, Grazi G, Nardo B, Guarnieri C, Bernardi M (2002) Evidence of oxidative imbalance in long-term liver transplant patients. Dig Liver Dis 34:279–284

    CAS  PubMed  Google Scholar 

  6. Corradini SG, Micheletta F, Natoli S, Iappelli M, Di Angelantonio E, De Marco R, Elisei W, Siciliano M, Rossi M, Berloco P, Attili AF, Diczfalusy U, Iuliano L (2005) High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. Liver Transpl 11:1494–1504

    PubMed  Google Scholar 

  7. Sokol RJ, Devereaux M, Dahl R, Gumpricht E (2006) “Let there be bile” understanding hepatic injury in cholestasis. J Pediatr Gastroenterol Nutr 43:S4–S9

    PubMed  Google Scholar 

  8. Floreani A, Baragiotta A, Martines R, Naccarato R, D’odorico A (2000) Plasma antioxidant levels in chronic cholestatic liver diseases. Aliment Pharmacol Ther 14:353–358

    CAS  PubMed  Google Scholar 

  9. Nagita A, Ando M (1997) Assessment of hepatic vitamin E status in adult patients with liver disease. Hepatology 16:392–397

    Google Scholar 

  10. Socha P, Koletzko B, Pawlowska J, Proszynska K, Socha J (1997) Treatment of cholestatic children with water-soluble vitamin E [alpha-tocopheryl polyethylene glycol succinate]: effects on serum vitamin E, lipid peroxides, and polyunsaturated fatty acids. J Pediatr Gastroenterol Nutr 24:189–193

    CAS  PubMed  Google Scholar 

  11. Sakrak O, Akpinar M, Bedirli A, Akyurek N, Aritas Y (2003) Short and long-term effects of bacterial translocation due to obstructive jaundice on liver damage. Hepatogastroenterology 50:1542–1546

    PubMed  Google Scholar 

  12. Thuy S, Ladurner R, Volynets V, Wagner S, Strahl S, Königsrainer A, Maier KP, Bischoff SC, Bergheim I (2008) Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr 138:1452–1455

    CAS  PubMed  Google Scholar 

  13. Bellot P, García-Pagán JC, Francés R, Abraldes JG, Navasa M, Pérez-Mateo M, Such J, Bosch J (2010) Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis. J Hepatol 52:2044–2052

    CAS  Google Scholar 

  14. Such J, Francés R, Muñoz C, Zapater P, Casellas JA, Cifuentes A, Rodríguez-Valera F, Pascual S, Sola-Vera J, Carnicer F, Uceda F, Palazón JM, Pérez-Mateo M (2002) Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites. Hepatology 36:135–141

    CAS  PubMed  Google Scholar 

  15. Wong F, Bernardi M, Balk R, Christman B, Moreau R, Garcia-Tsao G, Patch D, Soriano G, Hoefs J, Navasa M (2005) Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club. Gut 54:718–725

    PubMed Central  CAS  PubMed  Google Scholar 

  16. Tiao MM, Lin TK, Kuo FY, Huang CC, Du YY, Chen CL, Chuang JH (2007) Early stage of biliary atresia is associated with significant changes in 8-hydroxydeoxyguanosine and mitochondrial copy number. J Pediatr Gastroenterol Nutr 45:329–334

    CAS  PubMed  Google Scholar 

  17. Broide E, Klinowski E, Koukoulis G, Hadzic N, Portmann B, Baker A, Scapa E, Mieli-Vergani G (2000) Superoxide dismutase activity in children with chronic liver disease. J Hepatol 32:188–192

    CAS  PubMed  Google Scholar 

  18. Pessayre D, Mansouri A, Fromenty B (2002) Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis. Am J Physiol Gastrointest Liver Physiol 282:G193–G199

    CAS  PubMed  Google Scholar 

  19. Sokol RJ, Winklhofer-Roob BM, Devereaux MW, McKim JM Jr (1995) Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids. Gastroenterology 109:1249–1256

    CAS  PubMed  Google Scholar 

  20. Rodrigues CM, Steer CJ (2000) Mitochondrial membrane perturbations in cholestasis. J Hepatol 32(135):141

    Google Scholar 

  21. Codoner-Franch P, Muniz P, Gasco E, Domingo JV, Valls-Belles V (2008) Effect of diet supplemented with alpha-tocopherol and β-carotene on ATP and antioxidant levels after hepatic ischemia–reperfusion. J Clin Biochem Nutr 43:13–18

    PubMed Central  CAS  PubMed  Google Scholar 

  22. Sass DA, Reich DJ (2011) Liver transplantation in 21st century: expanding the donor options. Gastroenterol Clin North Am 40:641–658

    PubMed  Google Scholar 

  23. Chen XB, Xu MQ (2014) Primary graft dysfunction after liver transplantation. Hepatobiliary Pancreat Dis Int 13:125–137

    PubMed  Google Scholar 

  24. Ploeg RJ, D’Alessandro AM, Knechtle SJ, Stegall MD, Pirsch JD, Hoffmann RM, Sasaki T, Sollinger HW, Belzer FO, Kalayoglu M (1993) Risk factors for primary dysfunction after liver transplantation—a multivariate analysis. Transplantation 56:807–813

    Google Scholar 

  25. Clavien PA, Harvey PR, Strasberg SM (1992) Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies. Transplantation 53:957–978

    CAS  PubMed  Google Scholar 

  26. Detry O, Deroover A, Meurisse N, Hans MF, Delwaide J, Lauwick S, Kaba A, Joris J, Meurisse M, Honoré P (2014) Donor age as a risk factor in donation after circulatory death liver transplantation in a controlled withdrawal protocol programme. Br J Surg 101:784–792

    CAS  PubMed  Google Scholar 

  27. Reiniers MJ, van Golen RF, van Gulik TM, Heger M (2014) Reactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver. Antioxid Redox Signal 21(7):1119–1142

    PubMed Central  CAS  PubMed  Google Scholar 

  28. Cohen JC, Horton JD, Hobbs HH (2011) Human fatty liver disease: old questions and new insights. Science 332:15190–15123

    Google Scholar 

  29. Spitzer AL, Lao OB, Dick AA, Bakthavatsalam R, Halldorson JB, Yeh MM, Upton MP, Reyes JD, Perkins JD (2010) The biopsied donor liver: incorporating macrosteatosis into high-risk donor assessment. Liver Transpl 16:874–884

    PubMed  Google Scholar 

  30. El-Badry AM, Jang JH, Elsherbiny A, Contaldo C, Tian Y, Raptis DA, Laczko E, Moritz W, Graf R, Clavien PA (2011) Chemical composition of hepatic lipids mediates reperfusion injury of the macrosteatotic mouse liver through thromboxane A2. J Hepatol 55:1291–1299

    CAS  PubMed  Google Scholar 

  31. Gracia-Sancho J, García-Calderó H, Hide D, Marrone G, Guixé-Muntet S, Peralta C, García-Pagán JC, Abraldes JG, Bosch J (2013) Simvastatin maintains function and viability of steatotic rat livers procured for transplantation. J Hepatol 58:1140–1146

    CAS  PubMed  Google Scholar 

  32. Von Heesen M, Seibert K, Husler M, Scheuer C, Wagner M, Menger MD, Schilling MK, Moussavian MR (2012) Multidrug donor preconditioning protects steatotic liver grafts against ischemia-reperfusion injury. Am J Surg 203:168–76

    Google Scholar 

  33. Henry SD, Nachber E, Tulipan J, Stone J, Bae C, Reznik L, Kato T, Samstein B, Emond JC, Guarrera JV (2012) Hypothermic machine preservation reduces molecular markers of ischemia/reperfusion injury in human liver transplantation. Am J Transplant 12:2477–86

    CAS  PubMed  Google Scholar 

  34. Gonzalez-Flecha B, Cutrin JC, Boveris A (1993) Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia–reperfusion. J Clin Invest 91:456–464

    PubMed Central  CAS  PubMed  Google Scholar 

  35. Nishimura Y, Romer LH, Lemasters JJ (1998) Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured rat hepatic sinusoidal endothelial cells: the pH paradox and cytoprotection by glucose, acidotic pH, and glycine. Hepatology 27:1039–1049

    CAS  PubMed  Google Scholar 

  36. Blum H, Osbakken MD, Johnson RG Jr (1991) Sodium flux and bioenergics in the ischemic rat liver. Magn Reson Med 18:348–357

    CAS  PubMed  Google Scholar 

  37. Vollmar B, Glasz J, Leiderer R, Post S, Menger MD (1994) Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia–reperfusion. Am J Pathol 145:1421–1431

    PubMed Central  CAS  PubMed  Google Scholar 

  38. Atalla SL, Toledo-Pereyra LH, MacKenzie GH, Cederna JP (1985) Influence of oxygen-derived free radical scavengers on ischemic livers. Transplantation 40:584–590

    CAS  PubMed  Google Scholar 

  39. Ishii K, Suita S, Sumimoto H (1990) Effect of verapamil on conversion of xanthine dehydrogenase to oxidase in ischemic rat liver. Res Exp Med 190:389–399

    CAS  Google Scholar 

  40. Jaeschke H (2002) Xanthine oxidase-induced oxidant stress during hepatic ischemia–reperfusion: are we coming full circle after 20 years? Hepatology 36:761–763

    PubMed  Google Scholar 

  41. Nieminen AL, Byrne AM, Herman B, Lemasters JJ (1997) Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD[P]H and reactive oxygen species. Am J Physiol 272:C1286–C1294

    CAS  PubMed  Google Scholar 

  42. Arumugam TV, Magnus T, Woodruff TM, Proctor LM, Shiels IA, Taylor SM (2006) Complement mediators in ischemia-reperfusion injury. Clin Chim Acta 374:33–45

    CAS  PubMed  Google Scholar 

  43. Fondevila C, Busuttil RW, Kupiec-Weglinski JW (2003) Hepatic ischemia/reperfusion injury-a fresh look. Exp Mol Pathol 74:86–93

    CAS  PubMed  Google Scholar 

  44. Jaeschke H, Farhood A, Bautista AP, Spolarics Z, Spitzer JJ (1993) Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia. Am J Physiol 264:G801–G809

    CAS  PubMed  Google Scholar 

  45. Wanner GA, Ertel W, Müller P, Höfer Y, Leiderer R, Menger MD, Messmer K (1996) Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell activation. Shock 5:34–40

    CAS  PubMed  Google Scholar 

  46. Lentsch AB, Kato A, Yoshidome H, McMasters KM, Edwards MJ (2000) Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology 32:169–173

    CAS  PubMed  Google Scholar 

  47. Rudiger HA, Clavien PA (2002) Tumor necrosis factor-alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver. Gastroenterology 122:202–210

    CAS  PubMed  Google Scholar 

  48. Weiss SJ (1989) Tissue destruction by neutrophils. N Engl J Med 320:365–376

    CAS  PubMed  Google Scholar 

  49. Liu TZ, Lee KT, Chern CL, Cheng JT, Stern A, Tsai LY (2001) Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB. Ann Clin Lab Sci 31:383–390

    CAS  PubMed  Google Scholar 

  50. Bauer M, Bauer I (2002) Heme oxygenase-1: Redox regulation and role in the hepatic response to oxidative stress. Antioxid Redox Signal 4:749–758

    CAS  PubMed  Google Scholar 

  51. Pannen BH (2002) New insights into the regulation of hepatic blood flow after ischemia and reperfusion. Anesth Analg 94:1448–1457

    CAS  PubMed  Google Scholar 

  52. Harrison PM, Keays R, Bray GP, Alexander GJ, Williams R (1990) Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine. Lancet 335:1572–1573

    CAS  PubMed  Google Scholar 

  53. San-Miguel B, Alvarez M, Culebras JM, González-Gallego J, Tuñón MJ (2006) N-acetyl-cysteine protects liver from apoptotic death in an animal model of fulminant hepatic failure. Apoptosis 11:1945–1957

    CAS  PubMed  Google Scholar 

  54. Bucuvalas JC, Ryckman FC, Krug S et al (2001) Effect of treatment with prostaglandin E1 and N-acetylcysteine on pediatric liver transplant recipients: a singlecenter study. Pediatr Transplant 5:274–278

    CAS  PubMed  Google Scholar 

  55. Khan AW, Fuller BJ, Shah SR, Davidson BR, Rolles K (2005) A prospective randomized trial of N-acetyl cysteine administration during cold preservation of the donor liver for transplantation. Ann Hepatol 4(2):121–126

    CAS  PubMed  Google Scholar 

  56. Strubelt O, Younes M, Li Y (1994) Protection by albumin against ischaemia and hypoxia-induced hepatic injury. Pharmacol Toxicol 75:280–284

    CAS  PubMed  Google Scholar 

  57. Giakoustidis D, Papageorgiou G, Iliadis S, Kontos N, Kostopoulou E, Papachrestou A, Tsantilas D, Spyridis C, Takoudas D, Botsoglou N, Dimitriadou A, Giakoustidis E (2002) Intramuscular administration, of very high dose of alpha-tocopherol protects liver from severe ischemia/reperfusion injury. World J Surg 26:872–877

    PubMed  Google Scholar 

  58. Gondolesi GE, Lausada N, Schinella G, Semplici AM, Vidal MS, Luna GC, Toledo J, de Buschiazzo PM, Raimondi JC (2002) Reduction of ischemia-reperfusion injury in parenchymal and nonparenchymal liver cells by donor treatment with DL-alpha-tocopherol prior to organ harvest. Transplant Proc 34:1086–1091

    CAS  PubMed  Google Scholar 

  59. Cerwenka H, Khoschsorur G, Bacher H, Werkgartner G, El-Shabrawi A, Quehenberger F, Rabl H, Mischinger HJ (1999) Normothermic liver ischemia and antioxidant treatment during hepatic resections. Free Radic Res 30:463–469

    CAS  PubMed  Google Scholar 

  60. Soltys K, Dikdan G, Koneru B (2001) Oxidative stress in fatty livers of obese Zucker rats: rapid amelioration and improved tolerance to warm ischemia with tocopherol. Hepatology 34:13–18

    CAS  PubMed  Google Scholar 

  61. Codoñer-Franch P, Muñiz P, Gasco E, Domingo JV, Valls-Belles V (2008) Effect of a diet supplemented with alfa-tocopherol and β-carotene on ATP and antioxidant levels after hepatic ischemia-reperfusion injury. J Clin Biochem Nutr 43:13–18

    PubMed Central  PubMed  Google Scholar 

  62. Br J, Yeom D, Sm L (2001) Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver. Shock 15:112–117

    Google Scholar 

  63. Karwinski W, Soreide O (1997) Allopurinol improves scavenging ability of the liver after ischemia/reperfusion injury. Liver 17:139–143

    CAS  PubMed  Google Scholar 

  64. Moussavian MR, Kollmar O, Schmidt M, Scheuer C, Wagner M, Slotta JE, Gronow G, Justinger C, Menger MD, Schilling MK (2009) Amiodarone pretreatment of organ donors exerts anti-oxidative protection but induces excretory dysfunction in liver preservation and reperfusion. Liver Transpl 15:763–75

    PubMed  Google Scholar 

  65. My S, Sm L (2002) Protective effect of low dose of ascorbic acid on hepatobiliary function in hepatic ischemia/reperfusion in rats. J Hepatol 36:72–77

    Google Scholar 

  66. Gerbes AL, Vollmar AM, Kiemer AK, Bilzer M (1998) The guanylate cyclase-coupled natriuretic peptide receptor: a new target for prevention of cold ischemia–reperfusion damage of the rat liver. Hepatology 28:1309–1317

    CAS  PubMed  Google Scholar 

  67. Bilzer M, Jaeschke H, Vollmar AM, Paumgartner G, Gerbes AL (1999) Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide. Am J Physiol 276:G1137–G1144

    CAS  PubMed  Google Scholar 

  68. Amersi F, Nelson SK, Shen XD, Kato H, Melinek J, Kupiec-Weglinski JW, Horwitz LD, Busuttil RW, Horwitz MA (2002) Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc Natl Acad Sci U S A 99:8915–8920

    PubMed Central  CAS  PubMed  Google Scholar 

  69. Junnarkar SP, Tapuria N, Mani A, Dijk S, Fuller B, Seifalian AM, Davidson BR (2010) Attenuation of warm ischemia-reperfusion injury in the liver by bucillamine through decreased neutrophil activation and Bax/Bcl-2 modulation. J Gastroenterol Hepatol 25:1891–1899

    PubMed  Google Scholar 

  70. Aguilar-Melero P, Luque A, Machuca MM, Pérez de Obanos MP, Navarrete R, Rodríguez-García IC, Briceño J, Iñiguez M, Ruiz J, Prieto J, de la Mata M, Gomez-Villamandos RJ, Muntane J, López-Cillero P (2010) Cardiotrophin-1 reduces ischemia/reperfusion injury during liver transplant. J Surg Res 181:e83–91

    Google Scholar 

  71. Çekın AH, Gür G, Türkoğlu S, Aldemır D, Yilmaz U, Gürsoy M, Taşkoparan M, Boyacioğlu S (2013) The protective effect of L-carnitine on hepatic ischemia-reperfusion injury in rats. Turk J Gastroenterol 24:51–56

    PubMed  Google Scholar 

  72. Ben Mosbah I, Roselló-Catafau J, Alfany-Fernandez I, Rimola A, Parellada PP, Mitjavila MT, Lojek A, Ben Abdennebi H, Boillot O, Rodés J, Peralta C (2010) Addition of carvedilol to University Wisconsin solution improves rat steatotic and nonsteatotic liver preservation. Liver Transpl 16:163–171

    PubMed  Google Scholar 

  73. Song SW, Guo KI, Shi Y, Chang Y, Liu YF (2009) Pretreatment with calcitonin gene-related peptide attenuates hepatic ischemia/reperfusion injury in rats. Transplant Proc 41:1493–1498

    CAS  PubMed  Google Scholar 

  74. Konukoglu D, Tasci I, Cetinkale O (1998) Effects of cyclosporin A and ibuprofen on liver ischemia-reperfusion injury in the rat. Clin Chim Acta 275:1–8

    CAS  PubMed  Google Scholar 

  75. Yabe Y, Koyama Y, Nishikawa M, Takakura Y, Hashida M (1999) Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice. Free Radic Res 30:265–274

    CAS  PubMed  Google Scholar 

  76. Portakal O, Inal-Erden M (1999) Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia/reperfusion injury. Clin Biochem 32:461–466

    CAS  PubMed  Google Scholar 

  77. Park K, Chung KY, Sung SH, Kim BR, Kim YS (2003) Protective effect of desferrioxamine during canine liver transplantation: significance of peritransplant liver biopsy. Transplant Proc 35:117–119

    CAS  PubMed  Google Scholar 

  78. Tsuda T, Horio F, Kato Y, Osawa T (2002) Cyanidin 3-O-β-d-glucoside attenuates the hepatic ischemia-reperfusion injury through a decrease in the neutrophil chemoattractant production in rats. J Nutr Sci Vitaminol 48:134–141

    CAS  PubMed  Google Scholar 

  79. Ozaki M, Nakamura M, Teraoka S, Ota K (1997) Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia/reperfusion injury. Transpl Int 10:96–102

    CAS  PubMed  Google Scholar 

  80. Hori T, Uemoto S, Walden LB, Chen F, Baine AM, Hata T, Nguyen JH (2013) Pretreatment of small-for-size grafts in vivo by γ-aminobutyric acid receptor regulation against oxidative stress-induced injury in rat split orthotopic liver transplantation. Int J Hepatol 2013:149123

    PubMed Central  PubMed  Google Scholar 

  81. Zhong Z, Froh M, Connor HD, Li X, Conzelmann LO, Mason RP, Lemasters JJ, Thurman RG (2002) Prevention of hepatic ischemia-reperfusion injury by green tea extract. Am J Physiol Gastrointest Liver Physiol 283:G957–G964

    CAS  PubMed  Google Scholar 

  82. Schauer RJ, Gerbes AL, Vonier D, Meissner H, Michl P, Leiderer R, Schildberg FW, Messmer K, Bilzer M (2004) Glutathione protects the rat liver against reperfusion injury after prolonged warm ischemia. Ann Surg 239:220–231

    PubMed Central  PubMed  Google Scholar 

  83. Schauer RJ, Kalmuk S, Gerbes AL, Leiderer R, Meissner H, Schildberg FW, Messmer K, Bilzer M (2004) Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation. World J Gastroenterol 10:864–870

    CAS  PubMed  Google Scholar 

  84. Wieland E, Schütz E, Armstrong VW, Küthe F, Heller C, Oellerich M (1995) Idebenone protects hepatic microsomes against oxygen radical-mediated damage in organ preservation solutions. Transplantation 60:444–451

    CAS  PubMed  Google Scholar 

  85. Karaman A, Fadillioglu E, Turkmen E, Tas E, Yilmaz Z (2006) Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver. Pediatr Surg Int 22:428–434

    PubMed  Google Scholar 

  86. Grossini E, Pollesello P, Bellofatto K, Sigaudo L, Farruggio S, Origlia V, Mombello C, Mary DA, Valente G, Vacca G (2014) Protective effects elicited by levosimendan against liver ischemia/reperfusion injury in anesthetized rats. Liver Transpl 20:361–375

    PubMed  Google Scholar 

  87. Muller C, Dunschede F, Koch E, Vollmar AM, Kiemer AK (2003) Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway. Am J Physiol Gastrointest Liver Physiol 285:G769–G778

    PubMed  Google Scholar 

  88. Morsy MA (2011) Protective effect of lisinopril on hepatic ischemia/reperfusion injury in rats. Indian J Pharmacol 43:652–655

    PubMed Central  CAS  PubMed  Google Scholar 

  89. Xia Y, Rao J, Yao A, Zhang F, Li G, Wang X, Lu L (2012) Lithium exacerbates hepatic ischemia/reperfusion injury by inhibiting GSK-3β/NF-κB-mediated protective signaling in mice. Eur J Pharmacol 697:117–125

    CAS  PubMed  Google Scholar 

  90. Sánchez GM, Rodríguez HMA, Giuliani A, Núñez Sellés AJ, Rodríguez NP, León Fernández OS, Re L (2003) Protective effect of Mangifera indica L. extract [Vimang] on the injury associated with hepatic ischaemia reperfusion. Phytother Res 17:197–201

    PubMed  Google Scholar 

  91. Sewerynek E, Reiter RJ, Melchiorri D, Ortiz GG, Lewinski A (1996) Oxidative damage in the liver induced by ischemia–reperfusion: protection by melatonin. Hepatogastroenterology 43:898–905

    CAS  PubMed  Google Scholar 

  92. Zaoualí MA, Reiter RJ, Padrissa-Altés S, Boncompagni E, García JJ, Ben Abnennebi H, Freitas I, García-Gil FA, Rosello-Catafau J (2011) Melatonin protects steatotic and nonsteatotic liver grafts against cold ischemia and reperfusion injury. J Pineal Res 50:213–221

    PubMed  Google Scholar 

  93. Kotsch K, Ulrich F, Reutzel-Selke A, Pascher A, Faber W, Warnick P, Hoffman S, Francuski M, Kunert C, Kuecuek O, Schumacher G, Wesslau C, Lun A, Kohler S, Weiss S, Tullius SG, Neuhaus P, Pratschke J (2008) Methylprednisolone therapy in deceased donors reduces inflammation in the donor liver and improves outcome after liver transplantation: a prospective randomized controlled trial. Ann Surg 248:1042–1050

    PubMed  Google Scholar 

  94. Saidi RF, Chang J, Verb S, Brooks S, Nalbantoglu I, Adsay V, Jacobs MJ (2007) The effect of methylprednisolone on warm ischemia-reperfusion injury in the liver. Am J Surg 193:345–347

    CAS  PubMed  Google Scholar 

  95. Stoffels B, Yonezawa K, Yamamoto Y, Schäfer N, Overhaus M, Klinge U, Kalff JC, Minor T, Tolba RH (2011) Meloxicam, COX-2 inhibitor, ameliorates ischemia/reperfusion injury in non-heart-beating donor livers. Eur Surg Res 47:109–117

    CAS  PubMed  Google Scholar 

  96. Daglar G, Karaca T, Yuksek YN, Gozalan U, Akbiyik F, Sokmensuer C, Gurel B, Kama NA (2009) Effect of montelukast and MK-886 on hepatic ischemia-reperfusion injury in rats. J Surg Res 153:31–38

    CAS  PubMed  Google Scholar 

  97. Glantzounis GK, Yang W, Koti RS, Mikhailidis DP, Seifalian AM, Davidson BR (2004) Continuous infusion of N-acetylcysteine reduces liver warm ischaemia-reperfusion injury. Br J Surg 91:1330–1339

    CAS  PubMed  Google Scholar 

  98. Weigand MA, Plachky J, Thies JC, Spies-Martin D, Otto G, Martin E, Bardenheuer HJ (2001) N-Acetylcysteine attenuates the increase in alpha-glutathione S-transferase and circulating ICAM-1 and VCAM-1 after reperfusion in humans undergoing liver transplantation. Transplantation 72:694–698

    CAS  PubMed  Google Scholar 

  99. Yokota R, Fukai M, Shimamura T, Suzuki T, Watanabe Y, Nagashima K, Kishida A, Furukawa H, Hayashi T, Todo S (2000) A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. Surgery 127:661–669

    CAS  PubMed  Google Scholar 

  100. Singh AK, Mani H, Seth P, Gaddipati JP, Kumari R, Banuadha KK, Sharma SC, Kulshreshtha DK, Maheshwari RK (2000) Picroliv preconditioning protects the rat liver against ischemia-reperfusion injury. Eur J Pharmacol 395:229–239

    CAS  PubMed  Google Scholar 

  101. Wu TW, Fung KP, Wu J, Zeng LH, Nakamura H (1994) Propyl gallate as a hepatoprotector in vitro and in vivo. Biochem Pharmacol 48:419–422

    CAS  PubMed  Google Scholar 

  102. Boehnert MU, Armbruster FP, Hilbig H (2009) Relaxin as a protective substance in the preserving solution for liver transplantation. In: Fifth international conference on relaxin and related peptides, vol 1160. Annals of the New York Academy of Sciences. pp 320–321

    Google Scholar 

  103. Su JF, Guo CJ, Wei JY, Yang JJ, Jiang YG, Li YF (2003) Protection against hepatic ischemia-reperfusion injury in rats by oral pretreatment with quercetin. Biomed Environ Sci 16:1–8

    PubMed  Google Scholar 

  104. Ligeret H, Brault A, Vallerand D, Haddad Y, Haddad PS (2008) Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury. J Ethnopharmacol 12:507–514

    Google Scholar 

  105. Nguyen WD, Kim DH, Alam HB, Provido HS, Kirkpatrick JR (1999) Polyethylene glycol-superoxide dismutase inhibits lipid peroxidation in hepatic ischemia/reperfusion injury. Crit Care 3:127–130

    PubMed Central  CAS  PubMed  Google Scholar 

  106. Cheng F, Li Y, Feng L, Li S (2008) Effects of tetrandrine on ischemia/reperfusion injury in mouse liver. Transplant Proc 40:2163–2166

    CAS  PubMed  Google Scholar 

  107. Luo XY, Takahara T, Hou J, Kawai K, Sugiyama T, Tsukada K, Takemoto M, Takeuchi M, Zhong L, Li XK (2012) Theaflavin attenuates ischemia-reperfusion injury in a mouse fatty liver model. Biochem Biophys Res Commun 417:287–293

    CAS  PubMed  Google Scholar 

  108. Wu C, Wang P, Rao J, Wang Z, Zhang C, Lu L, Zhang F (2011) Triptolide alleviates hepatic ischemia/reperfusion injury by attenuating oxidative stress and inhibiting NF-kB activity in mice. J Surg Res 166:e205–213

    CAS  PubMed  Google Scholar 

  109. Yan S, Jin L-M, Liu Y-X, Zhou L, Xie H-Y, Zheng S-S (2010) Outcomes and mechanisms of ischemic preconditioning in liver transplantation. Hepatobiliary Pancreat Dis Int 9:346–354

    CAS  PubMed  Google Scholar 

  110. Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124–1136

    CAS  PubMed  Google Scholar 

  111. Sindram D, Rudiger HA, Upadhya AG, Strasberg SM, Clavien PA (2002) Ischemic preconditioning protects against cold ischemic injury through an oxidative stress dependent mechanism. J Hepatol 36:78–84

    PubMed  Google Scholar 

  112. Rüdiger HA, Graf R, Clavien PA (2003) Sub-lethal oxidative stress triggers the protective effects of ischemic preconditioning in the mouse liver. J Hepatol 39:972–977

    PubMed  Google Scholar 

  113. Terajima H, Enders G, Thiaener A, Hammer C, Kondo T, Thiery J, Yamamoto Y, Yamaoka Y, Messmer K (2000) Impact of hyperthermic preconditioning on postischemic hepatic microcirculatory disturbances in an isolated perfusion model of the rat liver. Hepatology 31:407–415

    CAS  PubMed  Google Scholar 

  114. Amador A, Grande L, Martí J, Deulofeu R, Miquel R, Solá A, Rodriguez-Laiz G, Ferrer J, Fondevila C, Charco R, Fuster J, Hotter G, García-Valdecasas JC (2007) Ischemic pre-conditioning in deceased donor liver transplantation: a prospective randomized clinical trial. Am J Transplant 7:2180–2189

    CAS  PubMed  Google Scholar 

  115. Koneru B, Shareef A, Dikdan G, Desai K, Klein KM, Peng B, Wachsberg RH, de la Torre AN, Debroy M, Fisher A, Wilson DJ, Samanta AK (2007) The ischemic preconditioning paradox in deceased donor liver transplantation—evidence from a prospective randomized single blind clinical trial. Am J Transplant 7:2788–2796

    CAS  PubMed  Google Scholar 

  116. Franco-Gou R, Roselló-Catafau J, Casillas-Ramirez A, Massip-Salcedo M, Rimola A, Calvo N, Bartrons R, Peralta C (2006) How ischaemic preconditioning protects small liver grafts. J Pathol 208:62–73

    CAS  PubMed  Google Scholar 

  117. Rehman H, Connor HD, Ramshesh VK, Theruvath TP, Mason RP, Wright GL, Lemasters JJ, Zhong Z (2008) Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation 85:1322–1331

    PubMed  Google Scholar 

  118. Coito AJ, Buelow R, Shen XD, Amersi F, Moore C, Volk HD, Busuttil RW, Kupiec-Weglinski JW (2002) Heme-oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia reperfusion injury. Transplantation 74:96–102

    CAS  PubMed  Google Scholar 

  119. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA (2006) Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Transpl 12:550–559

    PubMed  Google Scholar 

  120. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H, Brenner DA, Jude Samulski R, Zhong Z, Thurman RG (2000) Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. Hepatology 32(6):1255–1264

    CAS  PubMed  Google Scholar 

  121. Yabe Y, Kobayashi N, Nishihashi T, Takahashi R, Nishikawa M, Takakura Y, Hashida M (2001) Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives. J Pharmacol Exp Ther 298:3520–3526

    Google Scholar 

  122. He SQ, Zhang YH, Venugopal SK, Dicus CW, Perez RV, Ramsamooj R, Nantz MH, Zern MA, Wu J (2006) Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced live injury in mice. Liver Transpl 12:1869–1879

    PubMed  Google Scholar 

  123. Walther W, Stein U (2000) Viral vectors for gene transfer: a review of their use in the treatment of human diseases. Drugs 60:249–271

    CAS  PubMed  Google Scholar 

  124. Nagral A, Ben-Ari Z, Dhillon AP, Burroughs AK (1998) Eosinophils in acute cellular rejection in liver allografts. Liver Transpl Surg 4:355–362

    CAS  PubMed  Google Scholar 

  125. Foster PF, Sankary HN, Hart M, Ashmann M, Williams JW (1989) Blood and graft eosinophilia as predictors of rejection in human liver transplantation. Transplantation 47:72–74

    CAS  PubMed  Google Scholar 

  126. Salunga TL, Cui ZG, Shimoda S, Zheng HC, Nomoto K, Kondo T, Takano Y, Selmi C, Alpini G, Gershwin ME, Tsuneyama K (2007) Oxidative stress-induced apoptosis of bile duct cells in primary biliary cirrhosis. J Autoimmun 29:78–86

    CAS  PubMed  Google Scholar 

  127. Nagakawa Y, Williams GM, Zheng Q, Tsuchida A, Aoki T, Montgomery RA, Klein AS, Sun Z (2005) Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha. Hepatology 42:208–215

    CAS  PubMed  Google Scholar 

  128. Granot E, Elinav H, Kohen R (2002) Markers of oxidative stress in cyclosporine-treated and tacrolimus-treated children after liver transplantation. Liver Transpl 8:469–475

    PubMed  Google Scholar 

  129. Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N (2004) Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Br J Pharmacol 143:388–396

    PubMed Central  CAS  PubMed  Google Scholar 

  130. Garcia-Criado FJ, Palma-Vargas JM, Valdunciel-Garcia JJ, Toledo AH, Misawa K, Gomez-Alonso A, Toledo-Pereyra LH (1997) Tacrolimus [FK506] down-regulates free radical tissue levels, serum cytokines, and neutrophil infiltration after severe liver ischemia. Transplantation 64:594–598

    CAS  PubMed  Google Scholar 

  131. Krötz F, Keller M, Derflinger S, Schmid H, Gloe T, Bassermann F, Duyster J, Cohen CD, Schuhmann C, Klauss V, Pohl U, Stempfle HU, Sohn HY (2007) Mycophenolate acid inhibits endothelial NAD[P]H oxidase activity and superoxide formation by a Rac1-dependent mechanism. Hypertension 49:201–208

    PubMed  Google Scholar 

  132. Trapp A, Weis M (2005) The impact of immunosuppression on endothelial function. J Cardiovasc Pharmacol 45:81–87

    CAS  PubMed  Google Scholar 

  133. Wierzbicka A, Pawłowska J, Socha P, Jankowska I, Skorupa E, Teisseyre M, Ismail H, Czubkowski P, Socha J (2007) Lipid, carbohydrate metabolism, and antioxidant status in children after liver transplantation. Transplant Proc 39:1523–1525

    CAS  PubMed  Google Scholar 

  134. Jankowska I, Czubkowski P, Socha P, Wierzbicka A, Teisseyre M, Teisseyre J, Pawlowska J (2012) Lipid metabolism and oxidative stress in children after liver transplantation treated with sirolimus. Pediatr Transplant 16:901–906

    CAS  PubMed  Google Scholar 

  135. Samonte VA, Sherman PM, Taylor GP, Carricato MN, Fecteau A, Ling SC, Ng VL (2008) Scurvy diagnosed in a paediatric liver transplant patient awaiting combined kidney and liver transplantation. Pediatr Transplant 12:363–367

    PubMed  Google Scholar 

  136. Socha P, Litwin M (2008) Scurvy diagnosed in a pediatric liver transplant awaiting combined kidney and liver transplantation. Pediatr Transplant 12:257–260

    PubMed  Google Scholar 

  137. Hussein MH, Hashimoto T, Daoud GA, Kakita H, Kato S, Goto T, Hibi M, Kato T, Okumura N, Tomishige H, Hara F, Ito T, Fukuda S, Kato I, Suzuki T, Suzuki S, Togari H (2011) Oxidative stress after living related liver transplantation subsides with time in pediatric patients. Pediatr Surg Int 27:17–22

    PubMed  Google Scholar 

  138. Shapiro R, Halloran PF (2008) Organ preservation—can we do it better? Am J Transplant 8:479–480

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children’s Memorial Health Institute, Al. Dzieci Polskich 20, Warsaw, 04-730, Poland

    Piotr Czubkowski, Piotr Socha & Joanna Pawłowska

Authors
  1. Piotr Czubkowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Piotr Socha
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joanna Pawłowska
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Piotr Czubkowski .

Editor information

Editors and Affiliations

  1. Department of Health Sciences, University of Eastern Piedmont Amedeo Avogadro, Novara, Italy

    Emanuele Albano

  2. Department of Clinical and Biological Sciences, Unit of Experimental Medicine and Clinical Pathology, School of Medicine, University of Torino, Torino, Italy

    Maurizio Parola

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Czubkowski, P., Socha, P., Pawłowska, J. (2015). Oxidative Stress and Liver Transplantation. In: Albano, E., Parola, M. (eds) Studies on Hepatic Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Cham. https://doi.org/10.1007/978-3-319-15539-5_17

Download citation

Publish with us

Policies and ethics

Search

Navigation