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Supramolecular Hydrogels for Regenerative Medicine

  • Chapter
Supramolecular Polymer Networks and Gels

Part of the book series: Advances in Polymer Science ((POLYMER,volume 268))

Abstract

Regenerative medicine is the science of re-creating or repairing living functional tissue, often inside the body. Biomaterials for regenerative medicine are inspired by the extracellular matrix (ECM), which provides the natural scaffold for cells inside the body. The use of supramolecular hydrogels as man-made tunable replacements for the ECM is being investigated because hydrogels offer an aqueous environment. In addition, supramolecular systems offer modularity and dynamics, also found in the ECM. This chapter gives an overview of translational research on different supramolecular hydrogels, showing systems that have been used in vivo in the field of regenerative medicine. We discuss the chemical structures and biomedical applications of various natural compounds, biosynthetic compounds, biohybrid systems, and fully synthetic materials. Furthermore, we discuss tuning of the mechanical properties and functionalization of these hydrogels with bioactive compounds. Both characteristics are essential for their function in contact with cells and for the creation of a regenerative niche, thereby controlling cellular adherence, proliferation, homing, and differentiation.

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Acknowledgments

Our work is funded by the Ministry of Education, Culture and Science (Gravity program 024.001.035), the Netherlands Organisation for Scientific Research (NWO), the European Research Council (FP7/2007–2013) ERC Grant Agreement 308045, and conducted within the LSH TKI framework. The authors thank E.W. Meijer for many useful discussions.

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  1. Laboratory of Chemical Biology, Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands

    A. C. H. Pape & Patricia Y. W. Dankers

  2. Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

    A. C. H. Pape & Patricia Y. W. Dankers

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  1. A. C. H. Pape
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  2. Patricia Y. W. Dankers
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Correspondence to Patricia Y. W. Dankers .

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  1. Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany

    Sebastian Seiffert

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Pape, A.C.H., Dankers, P.Y.W. (2015). Supramolecular Hydrogels for Regenerative Medicine. In: Seiffert, S. (eds) Supramolecular Polymer Networks and Gels. Advances in Polymer Science, vol 268. Springer, Cham. https://doi.org/10.1007/978-3-319-15404-6_7

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