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The Intercalated Disc: A Focal Point for Sarcomere Growth and Disease

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Cardiac Cytoarchitecture

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Abstract

Heart muscle cells are glued together end to end by the intercalated disc (ID), a complex junction fulfilling many functions; it transduces the forces of contraction and transmits electrical signals from one cell to the next; it mechanically holds the cells together and is the site of other signalling pathways including those involved in calcium homeostasis. This chapter aims to describe the functional roles of the ID with respect to the observed structure. Particular emphasis is given to the relationship between myofibrils and the ID, and the evidence for cell growth and sarcomere addition at the ID is presented. Because of its complex nature, it is not surprising that the ID has been implicated in a number of heart diseases and malfunctions. Changes in its structure and composition associated with these heart problems are described with special regard to the role of the ID in dilated cardiomyopathy.

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  1. Randall Division of Cell and Molecular Biophysics, King’s College London, Guy’s Campus, London, SE1 1UL, UK

    Pauline M. Bennett

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  1. Randall Div. of Cell and Mol. Biophysics and Cardiovascular Division Guy’s Campus, Faculty of Life Sciences and Medicine King’s College London, London, United Kingdom

    Elisabeth Ehler

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Bennett, P.M. (2015). The Intercalated Disc: A Focal Point for Sarcomere Growth and Disease. In: Ehler, E. (eds) Cardiac Cytoarchitecture. Springer, Cham. https://doi.org/10.1007/978-3-319-15263-9_3

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