Abstract
Normal development and maintenance of the heart is determined by the balance between protein synthesis and degradation. The regulation of this balance is critical, as increased protein synthesis is linked to hypertrophy of the heart, whereas increased degradation is usually associated with atrophy. Hypertrophy and atrophy of the heart are just two examples of cardiomyopathies, where the cellular equilibrium between synthesis and degradation is out of balance. It has become increasingly clear that impaired degradation of cardiac proteins is associated with the development of many cardiomyopathies. Here we discuss the functions of cardiac waste disposal and recycling systems, examine their regulation, and summarize recent developments that outline how cardiac-specific as well as ubiquitously expressed components of the cellular degradation systems contribute to the development and maintenance of a healthy heart.
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Funding for S.L. was provided by a grant from the National Institute of Health, NHLBI (HL107744).
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Blondelle, J., Lange, S. (2015). Cardiac Cytoarchitecture: How to Maintain a Working Heart—Waste Disposal and Recycling in Cardiomyocytes. In: Ehler, E. (eds) Cardiac Cytoarchitecture. Springer, Cham. https://doi.org/10.1007/978-3-319-15263-9_12
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