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Cardiac Cytoarchitecture in Health and Disease

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Cardiac Cytoarchitecture

Abstract

Cardiomyocytes are distinguished by a particularly regularly arranged cytoskeleton. Both the myofibrils, which perform the contractile work of the heart, and the intercalated discs, a special type of cell–cell contact that serves for mechanical and electrochemical connection between individual cardiomyocytes, are multiprotein complexes that must be assembled in a regular fashion during development to guarantee a fully functional heart. In heart disease such as hypertrophic cardiomyopathy, dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy, these structures can be compromised in their composition and thus function. The aim of this chapter is to discuss how cardiac cytoarchitecture is established during development and how it is altered in disease.

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Authors and Affiliations

  1. Cardiovascular Division, BHF Centre of Research Excellence at King’s College London, London, UK

    Marlene Pluess & Elisabeth Ehler

  2. Randall Division of Cell and Molecular Biophysics, New Hunt’s House, Guy’s Campus, Room 3.26A, London, SE1 1UL, UK

    Marlene Pluess & Elisabeth Ehler

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  1. Marlene Pluess
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  2. Elisabeth Ehler
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Correspondence to Elisabeth Ehler .

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Editors and Affiliations

  1. Randall Div. of Cell and Mol. Biophysics and Cardiovascular Division Guy’s Campus, Faculty of Life Sciences and Medicine King’s College London, London, United Kingdom

    Elisabeth Ehler

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Pluess, M., Ehler, E. (2015). Cardiac Cytoarchitecture in Health and Disease. In: Ehler, E. (eds) Cardiac Cytoarchitecture. Springer, Cham. https://doi.org/10.1007/978-3-319-15263-9_1

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