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Effects of the High Calorie Diet on the Development of Chronic Visceral Disease

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High Calorie Diet and the Human Brain

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Abstract

Long term consumption of high calorie diet, which is enriched in saturated fats, cholesterol, and n-6 fatty acids, has been reported to not only cause the synthesis of proinflammatory lipid mediators (eicosanoids and platelet activating factor), proinflammatory cytokines (TNF-α, IL-1β, and IL-6), but also reported to upregulate the expression of gp91(phox) subunit of NADPH oxidase, and downregulates superoxide dismutase (SOD) and other detoxifying enzymes. High calorie diet consumption-mediated biochemical changes produce oxidative stress, and low grade inflammation. These processes promote weight gain, obesity and insulin resistance leading to type 2 diabetes and metabolic syndrome, a pathological condition, which is an important risk factor for cardiovascular disease, osteoporosis, arthritis, and various types of cancers.

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    Akhlaq A. Farooqui

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Farooqui, A.A. (2015). Effects of the High Calorie Diet on the Development of Chronic Visceral Disease. In: High Calorie Diet and the Human Brain. Springer, Cham. https://doi.org/10.1007/978-3-319-15254-7_8

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