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High Calorie Diet and the Human Brain pp 133–158Cite as

Effect of Soft Drink Consumption on Human Health

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Abstract

The consumption of artificial sweeteners is very popular because they are low in calories. Although, Food and Drug Administration has approved aspartame, acesulfame-k, neotame, cyclamate and alitame for use as per acceptable daily intake value, but it is becoming increasingly evident that breakdown products of these sweeteners may produce harmful metabolic effects in the visceral tissues and brain. Thus, aspartame is hydrolyzed into phenylalanine, aspartic acid, and methanol. Phenylalanine regulates neurotransmitters, whereas aspartic acid plays an important role in inducing excitotoxicity in the brain. Lastly methanol is oxidized into formaldehyde and diketopiperazine, a carcinogen, which mediates a number of other highly toxic effects. In experimental rats saccharin is known to cause bladder cancer. Steviol, a natural extract from the Stevia plant is a mutagen, but the safety of steviol glycoside as well as steviol oxidatives has been proven. Sucralose (Splenda™) is chlorinated sucrose, which is 600 times sweeter than sucrose. Sucralose has been reported to cause dizziness, head and muscle aches, stomach cramps, diarrhea, chronic inflammation and bladder issues in rodents and humans. So far studies performed on the safety of artificial sweeteners have been a major concerned due to their neurological effects and cancer-related issues.

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  1. Columbus, OH, USA

    Akhlaq A. Farooqui

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Farooqui, A.A. (2015). Effect of Soft Drink Consumption on Human Health. In: High Calorie Diet and the Human Brain. Springer, Cham. https://doi.org/10.1007/978-3-319-15254-7_5

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