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Genetic Considerations in Patients with Aortic Disease

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Endovascular Aortic Repair

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Abstract

The development of aortic endovascular repair has been a major advance in the treatment of aortic aneurysms and dissections. The use of endovascular repairs in patients with connective tissue disease has been limited due to concerns for device failure and they have been intentionally excluded from FDA trials. These patients form a subset of a larger group of patients with genetically triggered aortic disease. The aim of this chapter is to summarize the current body of knowledge about the genetics of syndromic (including connective tissue disease) and non-syndromic genetically triggered aortic aneurysms and dissections, diagnosis, current management, and role of endovascular repair in this population. Having a working knowledge of the known mutations leading to aortic aneurysms and dissections will allow the vascular surgeon to identify these patients and will facilitate early diagnosis and treatments tailored to the affected individuals.

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  1. Department of Surgery, Division of Vascular Surgery, University of Washington, 1959 NE Pacific Street, Box 356410, Seattle, WA, 98195, USA

    Sherene Shalhub

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  1. Division of Vascular and Endovascular Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA

    Gustavo S. Oderich

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Shalhub, S. (2017). Genetic Considerations in Patients with Aortic Disease. In: Oderich, G. (eds) Endovascular Aortic Repair. Springer, Cham. https://doi.org/10.1007/978-3-319-15192-2_3

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