Abstract
Previously, we have assessed the administration of chronic taurine (i.e. 0.05 % w/v for >4 weeks [c-Tau]) producing anxiogenic neurobehaviors, whereas acute taurine (i.e. 43 mg/kg/s.c. [a-Tau]) induces anxiolytic outcomes on anxiety based measures of behavior in the FVB/NJ mouse strain. Here we compared our findings with the FVB/NJ Fragile X knock out mouse (KO), the most inheritable form of intellectual disability characterized by a reduced efficiency in GABAergic signaling, to assess whether or not taurine, a GABAAR agonist, (i.e. acute and chronic) could stabilize and recover the emotional learning and memory profiles consistent with wild type (WT) mice. When compared to WT mice, KO mice exhibited reduced learning on the context fear task over four trials. Interestingly, both KO a-Tau and KO c-Tau evidenced recovered emotional learning acquisition during the context fear task when compared to KO which was comparable to WT; with marked improvements in the KO a-Tau condition more than the KO c-Tau. In addition, memory retention was increased in the KO a-Tau condition when compared to KO, while KO c-Tau was not significantly affected. These findings suggest that KO a-Tau treatment can be utilized as a potential pharmacotherapeutic intervention for treating KO’s in enhancing GABAergic modulation of emotional learning conditions consistent with this genetic disorder.
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Abbreviations
- a-Tau:
-
Acute taurine
- c-Tau:
-
Chronic taurine
- WT:
-
Wild type control mice
- KO:
-
Fragile X knockout mice
- CFC:
-
Context fear conditioning test
- ACFCT:
-
Auditory cued fear conditioning test
- FCX:
-
Frontal cortex
- HP:
-
Hippocampus
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Acknowledgements
We thank Ehab Jawad for his help with the behavioral studies. We thank Dr. Andrzej Weiraszko for his training and utilization of his synaptosomal equipment to conduct the aforementioned studies. We would like to thank the Louis Stokes Alliance for Minority Participation (LSAMP-NSF) and the CSI-CSTEP program for supporting author L.S. Neuwirth. This work was supported by PSC-CUNY and CSI.
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Neuwirth, L.S. et al. (2015). Taurine Recovers Mice Emotional Learning and Memory Disruptions Associated with Fragile X Syndrome in Context Fear and Auditory Cued-Conditioning. In: Marcinkiewicz, J., Schaffer, S. (eds) Taurine 9. Advances in Experimental Medicine and Biology, vol 803. Springer, Cham. https://doi.org/10.1007/978-3-319-15126-7_33
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DOI: https://doi.org/10.1007/978-3-319-15126-7_33
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