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Disorders of Thrombosis and Hemostasis in Pregnancy pp 41–57Cite as

Systemic Thromboembolism in Pregnancy: Heritable and Acquired Thrombophilias

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Abstract

Normal pregnancy is a hypercoagulable state. The predisposition to thrombosis may be exacerbated in women with heritable or acquired predisposition to thrombosis, known as thrombophilia. For a variety of reasons, the precise contribution of these thrombophilias to pregnancy morbidity is uncertain. However, there is evidence of an association between heritable thrombophilia and pregnancy morbidity including early and late pregnancy loss, preeclampsia, and intrauterine growth restriction. There also appears to be a weak association with placental abruption. Management of pregnant women with a thrombophilia relies on an accurate assessment of individual risk based on her personal and family history.

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Author information

Authors and Affiliations

  1. Department of Haematology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK

    Trevor Baglin MA, MB ChB, PhD, FRCP, FRCPath

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  1. Trevor Baglin MA, MB ChB, PhD, FRCP, FRCPath
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Correspondence to Trevor Baglin MA, MB ChB, PhD, FRCP, FRCPath .

Editor information

Editors and Affiliations

  1. Department of Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom

    Hannah Cohen

  2. Institute for Women's Health, University College London Hospitals NHS Foundation Trust, London, United Kingdom

    Patrick O'Brien

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Baglin, T. (2015). Systemic Thromboembolism in Pregnancy: Heritable and Acquired Thrombophilias. In: Cohen, H., O'Brien, P. (eds) Disorders of Thrombosis and Hemostasis in Pregnancy. Springer, Cham. https://doi.org/10.1007/978-3-319-15120-5_3

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  • DOI: https://doi.org/10.1007/978-3-319-15120-5_3

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-15119-9

  • Online ISBN: 978-3-319-15120-5

  • eBook Packages: MedicineMedicine (R0)

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