Abstract
Throughout the history of research into alkaptonuria (AKU), there have been many attempts to develop animal models to study the disorder. Several authors have fed experimental animals with diets high in phenylalanine or tyrosine and detected homogentisic acid in the urine (Papageorge and Lewis 1938; Butts et al. 1938; Abbott and Salmon 1943). In some of these studies, it was reported that dietary phenylalanine was more effective than a comparative amount of tyrosine in inducing alkaptonuria, and this effect has never been completely resolved. Despite the elevated urinary levels of homogentisic acid achieved in these animals, no evidence for the deposition of ochronotic pigment in tissues was reported in any of these studies.
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Gallagher, J.A. (2015). Experimental Alkaptonuria in Animals. In: Rovenský, J., Urbánek, T., Oľga, B., Gallagher, J. (eds) Alkaptonuria and Ochronosis. Springer, Cham. https://doi.org/10.1007/978-3-319-15108-3_8
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DOI: https://doi.org/10.1007/978-3-319-15108-3_8
Publisher Name: Springer, Cham
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