Skip to main content
SpringerLink
Log in

Development of the Haemopoiesis System before the Second Trimester of Pregnancy

  • Chapter
  • First Online:
Human Fetal Growth and Development

  • 1841 Accesses

Abstract

During embryogenesis the extra–embryonic yolk sac, fetal liver, preterm bone marrow and developing placenta are spatially and temporarily distinct sites where haemopoiesis occurs. Soon after the implantation of blastocyst erythropoiesis is established and primitive erythroid cells appear in Yolk Sac Blood Island by day 18th of gestation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 149.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 149.00
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Zon L. Developmental biology of hematopoiesis. Blood. 1995;86:2876.

    CAS  PubMed  Google Scholar 

  2. McGrath KE, Palis J. Hematopoiesis in the yolk sac: more than meets the eye. Exp Hematol. 2005;33:1021–8.

    Google Scholar 

  3. Bloom W, Bartelmez GW. Hematopoiesis in young human embryos. Am J Anat. 1940;67:21.

    Article  Google Scholar 

  4. Peschle C, Migliaccio AR, Migliaccio G, Ptrini M, Calandrini M, Russo G, et al. Embryonic to fetal Hb switch in humans: studies on erythroid bursts generated by embryonic progenitors from yolk sac and liver. Proc Natl Acad Sci USA. 1984;81:2416.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Migliaccio G, Migliaccio AR, Petti S, et al. Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac—liver transition. J Clin Invest. 1986;78:51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Emerson SG, Shanti T, Ferrara JL, Greenstein JL. Developmental regulation of erythropoiesis by hematopoietic growth factors: analysis on populations of BFU-E from bone marrow, peripheral blood, and fetal liver. Blood. 1989;74:49.

    CAS  PubMed  Google Scholar 

  7. Slayton WB, Juul SE, Calhoun DA, Li Y, Braylan RC, Christensen RD. Hematopoiesis in he liver and marrow of human fetuses at 5 to 16 weeks postconception: quantitative assessment of macrophage and neutrophil populations. Pediatr Res. 1998;43:774.

    Article  CAS  PubMed  Google Scholar 

  8. Gupta S, Pahwa R, O’Reilly R, et al. Ontogeny of lymphocyte subpopulation in human fetal liver. Proc Natl Acad Sci USA. 1976;73:919.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Rainaut M, Pagniez M, Hercend T, Daffos F, Forestier F. Characterization of mononuclear cell subpopulations in normal fetal peripheral blood. Hum Immunol. 1987;18:331.

    Article  CAS  PubMed  Google Scholar 

  10. Hann IM, Gibson BES, Letsky EA. Fetal and neonatal haematology. Philadelphia: Bailliere Tindall; 1991.

    Google Scholar 

  11. Cairo MS, Wagner JE. Placental and/or umbilical cord blood: an alternative source of hematopoietic stem transplantation. J Am Soc Hematol. 1997;90:4665.

    CAS  Google Scholar 

  12. Dame C, Fahnenstich H, Feitag P, Hofmann D, Abdul-Nour T, Bartmann P, Fandrey J. Erythropoietin mRNA expression in human fetal and neonatal tissue. Blood. 1998;92:3218.

    CAS  PubMed  Google Scholar 

  13. Grosveld F, van Assendelft GB, Greaves DR, Kolias B. Position independent, high-level expression of the human b globin gene in transgenic mice. Cell. 1987;51:975.

    Article  CAS  PubMed  Google Scholar 

  14. Hecht F, Motulsky AG, Lemire RJ, et al. Predominance of hemoglobin Gower 1 in early human embryonic development. Science. 1966;152:91.

    Article  CAS  PubMed  Google Scholar 

  15. Huehns ER, Dance N, Beaven GH, et al. Human embryonic hemoglobins. Cold Spring Harb Symp Quant Biol. 1964;29:327.

    Article  CAS  PubMed  Google Scholar 

  16. Bard H. The effect of placental insufficiency on fetal and adult hemoglobin synthesis. Am J Obstet Gynecol. 1974;120:67.

    Article  CAS  PubMed  Google Scholar 

  17. McCue CM, Garner FB, Hurt WG, et al. Placental transfusion. J Pediatr. 1968;72:15.

    Article  CAS  PubMed  Google Scholar 

  18. Pataryas HA, Stomatoyannopoulos G. Hemoglobins in human fetuses: evidence of adult hemoglobin production after the 11th gestational week. Blood. 1972;39:688.

    CAS  PubMed  Google Scholar 

  19. Thomas ED, Lochte Jr HL, Greenough III WB, et al. In vitro synthesis of foetal and adult haemoglobin by foetal haematopoietic tissues. Nature. 1960;185:396.

    Article  CAS  PubMed  Google Scholar 

  20. Kazazian HH, Woodhead AP. Hemoglobin A synthesis in the developing fetus. N Engl J Med. 1973;289:58.

    Article  CAS  PubMed  Google Scholar 

  21. Forestier F, Daffos F, Galacteros F, et al. Haematological values of 163 normal fetuses between 18 and 30 weeks of gestation. Paediatr Res. 1986;20:342.

    Article  CAS  Google Scholar 

  22. Millar DS, Davis LR, et al. Normal blood cell values in the early mid- trimester fetus. Prenat Diagn. 1985;5:367.

    Article  CAS  PubMed  Google Scholar 

  23. Linch DC, Knott LJ, et al. Studies of circulating hemopoietic progenitor cells in human fetal blood. Blood. 1982;59:976.

    CAS  PubMed  Google Scholar 

  24. Yao AC, Hirvensalo M, Lind J. Placental transfusion rate and uterine contraction. Lancet. 1968;1:380.

    Article  CAS  PubMed  Google Scholar 

  25. Fujiwara Y, Browne CP, Cuniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci USA. 1996;93:12355.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Porcellini A, Manna A, Manna M, et al. Ontogeny of granulocyte- macrophage progenitor cells in the human fetus. Int J Cell Cloning. 1983;1:92.

    Article  CAS  PubMed  Google Scholar 

  27. Nicola NA, Metcalf D. Specificity of action of colony-stimulating factors in the differentiation of granulocytes and macrophages. CIBA Found Symp. 1986;118:7.

    CAS  PubMed  Google Scholar 

  28. Cudennec CA, Johnson GR. Presence of multipotentialhemopoietic cells in teratocarcinoma cultures. J Embryol Exp Morphol. 1981;61:51.

    CAS  PubMed  Google Scholar 

  29. Carpenter KL, Turpen JB. Experimental studies on hemopoiesis in the pronephros of Rana pipiens. Differentiation. 1979;14:167.

    Article  CAS  PubMed  Google Scholar 

  30. Dieterlen-Lievre F. On the origin of hematopoietic stem cells in the avian embryo: an experimental approach. J Embryol Exp Morphol. 1975;33:607.

    CAS  PubMed  Google Scholar 

  31. Gale RE, Clegg JB, Huehns ER. Human embryonic haemoglobins Gower 1 and Gower 2. Nature. 1979;280:162.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Regenerative Medicine and Translational Science, Calcutta School of Tropical medicine, Kolkata, India

    Mainuddin Naskar MBBS

  2. Dr. Subhas Mukherjee, Chair Professor, Department of Regenerative Medicine and Translational Science, Director General of the Public Cord Blood Bank and Convener of Bidhan Chandra Roy Biorepository, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India

    Niranjan Bhattacharya Dsc, MD, MS, FSOG, FICS, FACS

Authors
  1. Mainuddin Naskar MBBS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Niranjan Bhattacharya Dsc, MD, MS, FSOG, FICS, FACS
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Niranjan Bhattacharya Dsc, MD, MS, FSOG, FICS, FACS .

Editor information

Editors and Affiliations

  1. Calcutta School of Tropical Medicine, Kolkata, India

    Niranjan Bhattacharya

  2. Boston University, Jamaica Plain, Massachusetts, USA

    Phillip G. Stubblefield

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Naskar, M., Bhattacharya, N. (2016). Development of the Haemopoiesis System before the Second Trimester of Pregnancy. In: Bhattacharya, N., Stubblefield, P. (eds) Human Fetal Growth and Development. Springer, Cham. https://doi.org/10.1007/978-3-319-14874-8_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-14874-8_32

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-14873-1

  • Online ISBN: 978-3-319-14874-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation