Abstract
The history of biomaterials started with gold and ivory, when these materials were used by the Egyptians and Romans before the twentieth century. Biomaterial is defined as any non-vital materials used in medical devices, intended to interact with biological systems. An important property that differentiates a biomaterial from other material is its biocompatibility. It is a term that is referred to as the appropriate host response to biomaterials. The understanding of biocompatibility is becoming an interdisciplinary study, since the biocompatibility of biomaterials is a critical issue in limiting device longevity and functionality. Biocompatibility is a multifactorial property, and it can be illustrated as a dynamic and an ongoing process. Some materials, such as amalgam, acrylic resin, and bis-GMA have been used for years in dentistry. On the other hand controversies still arise to debate the biocompatibility of those materials. Measuring the biocompatibility of a material is very complex. It is based on three levels of tests. Since there is no guarantee that a material is 100 % safe, all regulations and standards are related to the risk and safety of the materials. It is a challenge for biomaterials scientists to provide biomaterials with good biocompatibility that are able to serve for the best result of medical treatments. Gadjah Mada University as a leading university in Indonesia pays a great interest in the field of research. Some studies in developing local biomaterials and medical devices conducted by researchers of Gadjah Mada University are presented in this chapter.
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References
Ana, I. D., Matsuya, S., & Ishikawa, K. (2010). Engineering of carbonate apatite bone substitute based on composition-transformation of gypsum and calcium hydroxide. J Eng, 4, 344–352.
Anderson, J. M. (2001). Biological responses to materials. Annual Review of Materials Research, 31, 81–110.
Anusavice, K. J. (2003). Phillip’s science of dental materials (11th ed.) (pp. 170–190). Elsevier.
Anusavice, K. J., Shen, C., & Rawls, H. R. (2013)1. ). Phillip’s science of dental materials (12th ed.) (pp. 170–190). Elsevier.
Barralet, J., Akao, M., & Aoki, H. (2000). Dissolution of dense carbonate apatite subcutaneously implanted Wistar rats. Journal of Biomedical Materials Research, 49, 176.
Bergman, C. P., & Stumpf, A. (2013). Dental ceramics, topings in mining. Metallurgy and materials engineering. Heidelberg: Springer.
Bhat, V., Sharma, S. M., Shetty, V., Shastry, C. S., Rao, V., Shenoy, S. M., et al. (2013). Prevalence of Candida-associated denture stomatitis (CADS) and specification of Candida among complete denture wearers of south west coastral region of Karnataka. NUJHS, 3, 59–63.
Bhola, R., Bhola, S. M., Liang, H., & Mishra, B. (2010). Biocompatibility denture polymers—a review. Trends Biomater Artif Organs, 23, 129–136.
Browne, R. M. (1988). The in vitro assessment of the cytotoxicity of dental materials—does it have a role? International Endodontic, 21, 50–58.
Browne, R. M. (1994). Animal tests for biocompatibility of dental materials relevance, advantages and limitations. Journal of Dentistry, 22, 21–24.
Chee, W., & Jivraj, S. (2007). Failures in implant dentistry. British Dental Journal, 202, 123–129.
Chintalwar, S, A., Rajkapoor, B., & Ghode, P. D. (2012). Cytotoxicity of methanolic extract of pisoniaaculeata leaf. International Journal of Pharmacy and Biological Sciences, 3, 155–160.
Craig, R. G., & Powers, J. M. (2002). Restorative dental materials (11th ed.) (pp. 135–140). Mosby.
Dandekeri, S., Sowmya, M. K., & Bhandary, S. (2012). A maxillofacial rehabilitation with velopharyngeal obturator prosthesis. IJBR, 3, 285–287.
Dewo, P., Sharma, P. K., van der Tas, H. F., van der Houwen, E. B., Timmer, M., Magetsari, R., & Busscher, H. J. (2008a). Surface properties of Indonesian-made narrow dynamic compression plates. Medical Journal of Malaysia, 63, 21–23.
Dewo, P., Magetsari, R., Busscher, H. J., van Horn, J. R., & Verkerke, G. J. (2008b). Treating natural disaster victims is dealing with shortages – an orthopaedics perspective. Technical Health Care, 16, 255–259.
Dewo, P., Van Der Houwen, E. B., Sharma, P. K., Magetsari, R., Bor, T. C., Vargas Llona, L. D., Van Horn, J. R., Busscher, H. J., & Verkerke, G. J. (2012). Mechanical properties of Indonesian-made narrow dynamic compression plate. Journal of Mechanical Behavior of Biomedical Materials, 13, 93–101.
Dewo, P., van der Houwen, E. B., Suyitno, Marius, R., Magetsari, R., & Verkerked, G. J. (2015). Redesign of Indonesian-made osteosynthesis plates to enhance their mechanical behavior. Journal of Mechanical Behavior of Biomedical Materials, 42, 274–281.
Duplinsky, T. G., & Cicchetti, D. V. (2012). The health status of dentists exposed to mercury from silver amalgam tooth restorations. International Journal of Statistics in Medical Research, 1, 1–15.
Frinsken, K. W., Dandie, G. W., Lugowski, S., & Jordan, G. (2002). A study of titanium release into body organs following the insertion of single threaded screw implants into the mandibles of sheep. Australian Dental Journal, 47, 214–217.
Garoushi, S., Lassila, L., & Vallittu, P. K. (2011). Resin-based fiber-reinforced composite for direct replacement of missing anterior teeth- A clinical report. International Journal of Dental, 8455420.
Gautam, R., Singh, R. D., Sharma, V. P., Siddharta, R., Chand, P., & Kumar, R. (2012). Biocompatibility of polymethyl methacrylate resins used in dentistry. Journal of Biomedical Materials Research, 100, 1444–1450.
Gottenbos, B. (2001). The development of antimicrobial biomaterial surfaces. Thesis. pp. 10–13.
Herliansyah, M. K., Hamdi, M., Ektessabi, A. I., & Wildan, M. W. (2006). Fabrication of hydroxy-apatite bone graft for implant applications—literature study. In Proceeding of First International Conference on manufacturing and material processing (pp. 559–564). Kuala Lumpur, Malaysia.
Illeperuma, R. P., Park, Y. J., Kim, J. M., Bae, J. Y., Che, Z. M., Son, H. K., et al. (2012). Immortalized gingival fibrobalsts as a cytotoxicity test model for dental materials. Journal of Materials Science. Materials in Medicine, 23, 753–762.
Keong, L. C., & Hlim, A. S. (2009). In vitro models in biocompatibility assessment for biomedical grade chitosan derivatives in wound management. International Journal of Molecular Sciences, 10, 1300–1313.
Kirkpatrick, C. J., Peters, K., Hermanns, M. I., Bittinger, F., Krump-Konvalinkova, V., Fuchs, S., & Unger, R. E. (2005). In vitro methodologies to evaluate biocompatibility—status quo and perspective. ITBM RBM, 26, 192–199.
Kostoryz, E. L., Tong, P. Y., Chappelow, C. C., Eick, J. D., Glaros, A. G., & Yourtee, D. M. (1999). In vitro cytotoxicity of solid epoxy-based dental resins and their components. Ent Mat, 15, 363–373.
Landi, E., Tampieri, A., Celotti, G., Langenati, R., Shandri, M., & Sprio, S. (2005). Influence of synthesis and sintering parameters on the characteristics of calcium phosphate. Biomaterials, 26, 2835–2839.
Lassila, L. V. J., & Vallittu, P. K. (2001). Denture base polymer alldentsinomer—mechanical properties, water sorption and release of residual compounds. Journal of Oral Rehabilitation, 28, 607–613.
Lawrence, W. H., Dillingham, E. O., Turner, J. E., & Austian, J. (1972). Toxicity profile of chloroacetaldehyde. Journal of Pharmaceutical Sciences, 61, 19–25.
Leggat, P. A., & Kedjarune, U. (2003). Toxicity of methyl methacrylate in dentistry. International Dental Journal, 53, 126–131.
Lugoswki, S., Smith, D. C., & Bonek, H. (2000). Systemic metal ion levels in dental implant patientsafter five years. ActualitesenBiomateriaux, Paris France. Romillat, 401–409.
Lundin, K., Schmidt, G., & Bonde, C. (2013). Amalgam tattoo mimicking mucosal melanoma—a diagnostic dilemma revisited. Case Reports in Density, 787294.
Magetsari, R., Van Der Houwen, E. B., Bakker, M. T. J., Van Dr Mei, H. C., Verkerke, G. J., Rakhorst, G., Hilmy, C. R., Van Horn, J. R., & Busscher, H. J. (2006). Biomechanical and surface physico-chemical analyses of used osteosynthesis plates and screws—potential for reuse in developing countries. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 70, 453–460.
Malineni, S. K., Nuvvula, S., Matinlinna, J. P., Yiu, C. K., & King, N. M. (2013). Biocompatibility of various dental materials in contemporary dentistry—a narrative insight. The Journal of Clinical Dentistry, 4, 9–19.
Mehta, R. (2015). Powder metallurgy processing for low-cost titanium. In Materials world magazine. http://www.iom3.org/news/powder-metallurgy-processing-low-cost-titanium.
Moharamzadeh, K., van Noort, R., Brook, I. M., & Scutt, A. M. (2007). Cytotoxicity of resin monomers on human gingival fibroblast and HaCaT keratinocytes. Dental Materials, 23, 40–44.
Murray, P. E., Godoy, C. G., & Godoy, F. G. (2007). How is the biocompatibility of dental materials evaluated? Medicina Oral, Patología Oral y Cirugía Bucal, 12, 258–256.
Mutter, J. (2011). Is dental amalgam safe for humans? The opinion of the scientific committee of the European commission. Journal of Occupational Medicine, 6, 8–17.
Nalcaci, A., Oxcan, M. D., & Yilmaz, S. (2006). Citotoxicity of composite resins polymerized with different curing methods. International Endodontic Journal, 37, 151–156.
Nayak, Y., Rana, R. P., & Pratihar, S. K. (2008). Pressureless sintering of dense hydro-xyapatite- zirconia composites. Journal of Material Science, 19, 2437–2444.
Noor, A. F. M., Kasim, S. R., Othman, R., Ana, I. D., & Ishikawa, K. (2013). Synthesis of biphasic calcium phosphate by hydrothermal route and conversion to porous sintered scaffold. JBNB, 4, 273–278.
Onuki, Y., & Bhardwajd, U. (2008). A review of the biocompatibility of implantable devices—current challenges to overcome foreign body response. Journal of Diabetes Science and Technology, 2, 1003–1010.
Ozcan, M., & Hammerle, C. (2012). Titanium as a reconstruction and implant material in dentistry- Advantages and pitfalls. Materials, 5, 1528–1545.
Ozen, J., Sipahi, C., Caglar, A., & Dalkiz, M. (2006). In vitro cytotoxicity of glass and carbon fiber-reinforced heat-polymerized acrylic resin denture base material. Turkish Journal of Medical Sciences, 36, 121–126.
Phillips, R. W. (1989). Skinner’s Science of Dental Materials (8th ed.). Philadelphia: WB Saunders Co.
Pleva, J. (1994). Dental mercury– A public health hazard. Reviews on Environmental Health, 10, 1–27.
Pradeep, N., & Sreekumar, V. (2012). An in vitro investigation into the cytotoxicity of methyl methacrylate monomer. Journal of Contemporary Dental Practice, 6, 838–841.
Pujiyanto, E., Siswomihardjo, W., Ana, I. D., Tontowi, A. E., & Wildan, M. W. (2006). Cytotoxicity of hydroxyapatite synthesized from local gypsum. In BME days proceeding (pp. 92–95). Bandung.
Pujiyanto, E., Tontowi, A. E., Wildan, M. W., & Siswomihardjo, W. (2013). Preparation of porous hydroxyapatite as synthetic scaffold using powder deposition and sintering and cytotoxicity evaluation. Advanced Materials Research, 747, 123–126.
Quan, R., Yang, D., Wu, X., Wang, H., Miao, X., & Li, W. (2008). In vitro and in vivo biocompatibility of graded hydroxyapatite – zirconia composite bioceramic. Journal Materials Science, 19, 183–187.
Ratner, B.D., Hoffman, A. S., Schoen, F. J., & Lemons, J. E. (2004). Biomaterials science—an introduction to materials in medicine. Elsevier.
Sakaguchi, R. L., & Powers, J. M. (2012). Craig’s restorative dental materials (13th ed.) (pp. 110–128). Elsevier.
Salerno, C., Pascale, M., Contaldo, M., Esposito, V., Busciolano, M., Milillo, L., Guida, A., Petruzzi, M., & Serpico, R. (2011). Candida associated denture stomatitis. Med Oral Patol Oral Cir Bucal Mar, 16, 139–143.
Schmalz, G., & Arenholt-Bindslev, D. (2009). Biocompatibility of dental materials. Heidelberg: Springer.
Scott, R. M. (1990). Preventing and treating shunt complications. Concepts Neurosurg, 3, 115–121.
Sideridou, I., Achilias, D. S., Spyroudi, C., & Karabela, M. (2004). Water sorption characteristics of light-cured dental resins and composites based on Bis-EMA/PCDMA. Journal of Biomaterials, 25, 367–376.
Simon, C. G., Antonuci, J. M., Liu, D. W., & Skrtic, D. (2005). In vitro cytotoxicity of amorphous calcium phosphate composites. Journal of Bioactive and Compatible Polymers, 20, 279–295.
Singh, R., & Dahotre, N. B. (2007). Corrosion degradation prevention by surface modification of biometallic materials. Journal of Materials Science. Materials in Medicine, 18, 725–751.
Siswomihardjo, W., Sunarintyas, S., & Tontowi, A. E. (2012). The effect of zirconia in hydroxyapatite on Staphylococcus epidermidis growth. International Journal of Biomaterials, 432372.
Soni, R., Bhatnagar, A., Vivek, R., Singh, R., Chaturvedi, T. P., & Singh, A. (2012). A systemic review on mercury toxicity from dental amalgam fillings and its management strategies. Journal of Scientometric Research, 56, 81–92.
Sudiharto, P. (2002). Ventriculoperitoneal shunt using new semilunar valve system for hydrocephalus in infants and children. Indonesia Journal of Clinical Epidemiology and Biostatistics, 9, 56–65.
Sweeney, M., Creanor, S. L., Smith, R. A., & Foye, R. H. (2012). The release of mercury from dental amalgam and potential neurotoxicological effects. Journal of Dentistry, 30, 243–250.
Tang, A. T. H. (2014). Biocompatibility in Handbook of oral biomaterials (pp. 173–176). Pan Stanford Pub.
Temenoff, J. S., & Mikos, A. G. (2008). Biomaterials—the intersection of biology and materials science (pp. 1–13). Pearson Int Ed.
Triyono, J., Tontowi, A. E., Siswomihardjo, W., & Rochmadi. (2015). Tensile strength test of photo biocomposites for application in biomedical materials. Applied Mechanics and Materials, 699, 411–415.
Tuan Rahmi, T. N. A., Mohamad, D., Akil, H. M., & Abdul Rahman, I. (2012). Water sorption characteristics of restorative dental composites immersed in acidic drinks. Dental Materials, 28, 63–70.
Ucar, Y., & Brantley, W. (2011). Biocompatibility of dental amalgams. International Journal of Dentistry, 981595.
van den Berghe, F., Cornillie, P., Stegen, L., van Goethem, B., & Simoens, P. (2010). Palatoschizis in the dog—development mechanisms and etiology. Vlaams Diergeneeskunde Tijdschrift, 79, 117–123.
van Tienhoven, E. A. E., Korbee, D., Sshipper, L., Verharen, H. W., & de Jong, W.-H. (2006). In vitro and in vivo (cyto)toxicity assays using PVC and LDPE as model materials. Journal of Biomedical Materials Research Part A, 78, 175–182.
Wang, Q., Ge, S., & Zhang, D. (2004). Highly bioactive nano-hydroxyapatite partially stabilized zirconia ceramics. Journal of Bionic Engineering, 1, 215–220.
Wataha, J. C. (2001). Principles of biocompatibility for dental practioners. Journal of Prosthetic Dentistry, 86, 203–209.
Wataha, J. C., Hanks, C. T., Strawn, S., & Fat, G. C. (1994). Cytotoxicity of components of resins and other dental restorative materials. Journal of Oral Pathology, 10, 101–112.
Wiliams, D. F. (2008). On the mechanisms of biocompatibility. Biomaterials, 29, 2941–2953.
Woodman, J. L., Jacobs, J. J., Galante, J. O., & Urban, R. M. (1984). Metal ion release from titanium based prosthetic segmental replacements of long bones in baboons—A long term study. Journal of Orthopaedic Research, 1, 421–430.
Zhang, M., & Matinlinna, J. P. (2012). E-glass fiber-reinforced composites in dental applications. Silicon, 4, 73–78.
Acknowledgement
My special thanks goes to my colleagues P. Sudiharto, H. Dedy Kusuma, B. Primario Wicaksono, MG. Widiastuti, Punto Dewo, Ika Dewi Ana, H. Agung Pribadi, Purnomo and Y. Novian Paramarthanto who supported me with pictures, references, suggestions and fruitful discussions in completing this chapter.
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Siswomihardjo, W. (2016). Biocompatibility Issues of Biomaterials. In: Mahyudin, F., Hermawan, H. (eds) Biomaterials and Medical Devices. Advanced Structured Materials, vol 58. Springer, Cham. https://doi.org/10.1007/978-3-319-14845-8_3
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