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Plasticisers Used in PVC for Foods: Assessment of Specific Migration

  • Luciana BolzoniEmail author
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Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)

Abstract

The use of polyvinyl chloride (PVC) in food packaging is mainly related to the plasticity of the same material when used in wrapping films and in gaskets for metal closures (applications: glass jars and bottles). Anyway, main required characteristics are the flexibility, the softness and the possibility of being used for wrapping films and hermetic closures. Pure PVC is a rigid material, but it may also be mixed in remarkable proportions with other substances: the final product may become flexible, soft and plastic. Many plasticisers may be used in the European Union in accordance with the Regulation (EU) No. 10/2011 on plastic materials and articles intended to come into contact with food. In relation to food contact-approved PVC materials, inglobated plasticisers can gradually migrate from the plasticised object to foods depending on the influence of factors such as the temperature or the physical medium (solvent, food). The Regulation (EU) No. 10/2011 provides specific migration limits for different plasticisers. The analytical control of these limits in foods and/or in food simulants is important by the viewpoint of food safety. Currently available and used methods for the evaluation of specific migration are reviewed in this paper.

Keywords

Gas chromatography High-performance liquid chromatography Mass spectrometry Phthalate Plasticiser Polyvinyl chloride QuEChERS Specific migration limit 

Abbreviations

acPG

Acetylated partial glycerides

AFC

Panel on food additives, flavouring, processing aids and materials in contact with food

ATBC

Acetyl tributyl citrate

BBP

Benzyl butyl phthalate

BBPd4

Benzyl butyl phthalate deuterated

DEHA

Bis-ethylhexyl adipate

DINCH

1,2-Cyclohexane dicarboxylic acid, diisononyl ester

DBP

Dibutyl phthalate

DBPd4

Dibutyl phthalate deuterated

DBS

Dibutyl sebacate

DCP

Dicyclohexyl phthalate

DEHP

Di(2-ethylhexyl) phthalate

DEHPd4

Di(2-ethylhexyl) phthalate deuterated

DEP

Diethyl phthalate

DEPd4

Diethyl phthalate deuterated

DEHS

Di-2-ethylhexyl sebacate

DIBP

Diisobutyl phthalate

DIDP

Diisodecyl phthalate

DINP

Diisononyl phthalate

DMG

Dimethyl glutarate

DMP

Dimethyl phthalate

DMPi

Dimethyl pimelate

DMS

Dimethyl sebacate

DPP

Di-n-propyl phthalate

DOP

Dioctyl phthalate

DOPd4

Dioctiyl phthalate deuterated

DpeP

Dipentyl phthalate

ESBO

Epoxidised soybean oil

EFSA

European Food Safety Authority

SSICA

Experimental Station for the Food Preserving Industry

FID

Flame ionisation detector

GC

Gas chromatography

GC/MS

Gas chromatography/mass spectrometry

HPLC

High-performance liquid chromatography

LC

Liquid chromatography

LC/MS

Liquid chromatography/mass spectrometry

LC/MS/MS

Liquid chromatography/tandem mass spectrometry

MW

Molecular weight

MgSO4

Magnesium sulphate

PVC

Polyvinyl chloride

PSA

Primary and secondary amines

QuEChERS

Quick, Easy, Cheap, Effective, Rugged and Safe

RPLC

Reversed-phase liquid chromatography

SML

Specific migration limit

THF

Tetrahydrofuran

References

  1. 1.
    EFSA (2005) Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to Bis(2-ethylhexyl)phthalate (DEHP) for use in food contact materials. EFSA J 243:1–20. doi: 10.2903/j.efsa.2005.243 Google Scholar
  2. 2.
    European Parliament and Council (2005) Directive 2005/84/EC of the European Parliament and of the Council of 14 Dec 2005 amending for the 22nd time Council Directive 76/769/EEC on the approximation of the laws, regulations and administrative provisions of the member states relating to restrictions on the marketing and use of certain dangerous substances and preparations (phthalates in toys and childcare articles). Off J Eur Union L344:40–43Google Scholar
  3. 3.
    Commission European (2011) Commission Regulation (EU) No. 10/2011 of 14 Jan 2011 on plastic materials and articles intended to come into contact with food. Off J Eur Union L12:1–88Google Scholar
  4. 4.
    EFSA (2005) Opinion of the scientific panel on food additives, flavouring, processing aids and materials in contact with food (AFC) on a request from the commission related to butylbenzylphthalate (BBP) for use in food contact materials. EFSA J 241:1–14. doi: 10.2903/j.efsa.2005.241 Google Scholar
  5. 5.
    EFSA (2005) Opinion of the scientific panel on food additives, flavouring, processing aids and materials in contact with food (AFC) on a request from the commission related to di-butylphthalate (DBP) for use in food contact materials. EFSA J 242:1–17. doi: 10.2903/j.efsa.2005.242 Google Scholar
  6. 6.
    EFSA (2005) Opinion of the scientific panel on food additives, flavouring, processing aids and materials in contact with food (AFC) on a request from the commission related to di-isodecylphthalate (DIDP) for use in food contact materials. EFSA J 245:1–14. doi: 10.2903/j.efsa.2005.245 Google Scholar
  7. 7.
    EFSA (2005) Opinion of the scientific panel on food additives, flavouring, processing aids and materials in contact with food (AFC) on a request from the commission related to di-isononylphthalate (DINP) for use in food contact materials. EFSA J 244:1–18. doi: 10.2903/j.efsa.2005.244 Google Scholar
  8. 8.
    Fantoni L, Simoneau C (2003) European survey of contamination of homogenized baby food by epoxidized soybean oil migration from plasticized PVC gaskets. Food Addit Contam 20:1087–1096. doi: 10.1080/02652030310001615186 CrossRefGoogle Scholar
  9. 9.
    Fankauser Noti A, Fiselier K, Biedermann S, Grob K, Armellini F, Rieger K, Skjevrak I (2005) Epoxidized soybean oil (ESBO) migrating from the gaskets of lids into food packed in glass jars. Eur Food Res Technol 221:416–442. doi: 10.1007/s00217-005-1194-4 CrossRefGoogle Scholar
  10. 10.
    European Commission (2007) Commission Regulation No. 372/2007 laying down transitional migration limits for plasticisers in gaskets in lids intended to come into contact with foods. Off J Eur Union L92:9–12. Amended by European Commission (2008) Commission Regulation No. 597/2008 Off J Eur Union L164:12–13 on transitional migration limits for plasticisers in gasket in lids intended to come into contact with foodsGoogle Scholar
  11. 11.
    Welle F, Wolz G, Franz R (2004) Study on the migration behaviour of DEHP versus an alternative plasticiser, Hexamoll® DINCH, from PVC tubes into enteral feeding solutions. Poster presented at the 3rd international symposium on food packaging, Barcelona, 17–19 Nov 2004Google Scholar
  12. 12.
    Petersen JH, Brendahl T (2000) Plasticizers in total diet samples, baby food and infant formulae. Food Addit Contam 17:133–141. doi: 10.1080/026520300283487 CrossRefGoogle Scholar
  13. 13.
    Fankhauser-Noti A, Grob K (2006) Injector-internal thermal desorption from edible oils performed by programmed temperature vaporizing (PTV) injection. J Sep Sci 29:2365–2374. doi: 10.1002/jssc.200600064 CrossRefGoogle Scholar
  14. 14.
    Tsumura Y, Ishimitsu S, Saito I, Sakai H, Tsuchida Y, Tonogai Y (2003) Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan. Food Addit Contam 20(4):317–324. doi: 10.1080/0265203031000122021 CrossRefGoogle Scholar
  15. 15.
    Fusari P, Rovellini P (2009) Liquid chromatography-Ion Trap-ESI-mass spectrometry in food safety assessment: phthalates in vegetable oils. Riv Ital Sostanze Grasse 86(1):25–30Google Scholar
  16. 16.
    Dirwono W, Nam YS, Park HM, Lee KB (2013) LC-TOF/MS determination of phthalates in ediblesalts from food markets in Korea. Food Addit Contam B Surveill 6(3):203–208. doi: 10.1080/19393210.2013.795194 CrossRefGoogle Scholar
  17. 17.
    Sannino A (2010) Development of a gas chromatographic/mass spectrometric method for determination of phthalates in oily foods. J AOAC Int 93(1):315–322Google Scholar
  18. 18.
    Technical Committee CEN/TC 275 (2008) EN 15662:2008. Foods of plant origin—determination of pesticide residues using GC-MS and/or LC-MS/MS following acetonitrile extraction/partitioning and clean-up by dispersive SPE—QuEChERS-method. European Committee for Standardization, BrusselsGoogle Scholar
  19. 19.
    Castle L, Sharman M, Gilbert J (1988) Gas chromatographic-mass spectrometric determination of epoxidized soybean oil contamination of foods by migration from plastic packaging. J Assoc Off Anal Chem 71(6):1183–1186Google Scholar
  20. 20.
    Fankhauser-Noti A, Fiselier K, Biedermann-Brem S, Grob K (2005) Epoxidized soy bean oil migrating from the gaskets of lids into food packed in glass jars: analysis by on-line liquid chromatography-gas chromatography. J Chromatogr A 1082:214–218. doi: 10.1016/j.chroma.2005.05.057 CrossRefGoogle Scholar
  21. 21.
    Biedermann-Brem S, Biedermann M, Fankhauser-Noti A, Grob K, Helling R (2007) Determination of epoxidized soy bean oil (ESBO) in oily foods by GC–FID or GC–MS analysis of the methyl diepoxy linoleate. Eur Food Res Technol 224(3):309–314. doi: 10.1007/s00217-006-0424-8 CrossRefGoogle Scholar
  22. 22.
    Suman M, La Tegola S, Catellani D, Bersellini U (2005) Liquid chromatography-electrospray ionization-tandem mass spectrometry method for the determination of epoxidized soybean oil in food products. J Agric Food Chem 53(26):9879–9884. doi: 10.1021/jf052151x CrossRefGoogle Scholar
  23. 23.
    Castle L, Mercer AJ, Gilbert J (1988) Gas chromatographic-mass spectrometric determination of adipate-based polymeric plasticizers in foods. J Assoc Off Anal Chem 71(2):394–396Google Scholar
  24. 24.
    Biedermann M, Grob K (2006) GC Method for determining polyadipate plasticizers in foods: transesterification to dibutyl adipate, conversion to migrating polyadipate. Chromatographia 64:543–552. doi: 10.1365/s10337-006-0071-z CrossRefGoogle Scholar
  25. 25.
    Biederman M, Grob K (2006) GC–MS characterization of oligomers in polyadipates used as plasticizers for PVC in food contact. Packag Technol Sci 19:159–178. doi: 10.1002/pts.722 CrossRefGoogle Scholar
  26. 26.
    Graubardt N, Biedermann M, Fiselier K, Bolzoni L, Pedrelli T, Cavalieri C, Simoneau C, Grob K (2009) Search for a more adequate test to predict the long-term migration from the PVC gaskets of metal lids into oily foods in glass jars. Food Addit Contam A 26(7):1113–1122. doi: 10.1080/02652030902894405 CrossRefGoogle Scholar
  27. 27.
    Graubardt N, Biedermann M, Fiselier K, Fiselier L, Bolzoni L, Cavalieri C, Grob K (2009) Further insights into the mechanism of migration from PVC gaskets of metal closures into oily foods in glass jars. Food Addit Contam A 26(8):1217–1225. doi: 10.1080/02652030902950835 CrossRefGoogle Scholar
  28. 28.
    McCombie G, Harling-Vollmer A, Morandini M, Schmäschke G, Pechstein S, Altkofer W, Biedermann M, Biedermann-Brem S, Zurfluh M, Sutter G, Landis M, Grob K (2012) Migration of plasticizers from the gaskets of lids into oily food in glass jars: a European enforcement campaign. Eur Food Res Technol 235(1):129–137. doi: 10.1007/s00217-012-1739-2 CrossRefGoogle Scholar

Copyright information

© The Author(s) 2015

Authors and Affiliations

  1. 1.Experimental Station for the Food Preserving Industry (SSICA)ParmaItaly

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