Abstract
Imaging protocols in Cardiac MRI, PET and SPECT provide a rich set of tools for the evaluation of myocardial scar, edema, inflammation, anatomy, functional abnormalities and associated features of cardiac sarcoidosis. Cardiac magnetic resonance imaging (MRI) employs delayed hyperenhancement (DHE) sequences for the detection of bright (high signal intensity) scar in the myocardium as well as T2 imaging for inflammation and cinematic movie imaging for anatomic and functional evaluation. PET/CT assesses for hypermetabolic inflammation within the myocardium using a PET protocol designed to suppress normal myocardial glucose uptake. Nuclear medicine Technetium (99mTc) sestamibi myocardial single-photon emission computed tomography (SPECT) assesses for “reverse distribution”, perfusion abnormalities seen on rest imaging that are not present on stress imaging that may suggest microvascular constriction in myocardial sarcoidosis. However, Cardiac MRI, PET and SPECT imaging modalities are not individually specific for cardiac sarcoidosis and the role of imaging in the diagnosis and followup of cardiac sarcoidosis requires careful integration with laboratory and clinical data.
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Schroeder, J.D., Fenster, B. (2015). Diagnosis II: Imaging of Cardiac Sarcoidosis with Cardiac MRI, PET and SPECT. In: Freeman, A., Weinberger, H. (eds) Cardiac Sarcoidosis. Springer, Cham. https://doi.org/10.1007/978-3-319-14624-9_5
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DOI: https://doi.org/10.1007/978-3-319-14624-9_5
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