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Cardiac Sarcoidosis pp 5–10Cite as

Pathophysiology: From Genetics to Viruses and More

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Abstract

Sarcoidosis is thought to occur in patients with some sort of genetic susceptibility in combination with an environmental exposure. The exact mechanisms are multifactorial and unclear, despite numerous leads explored over the years. Genetic foci, viruses, fungi, and environmental toxins have all been shown to be potentially involved in the development of the disease. Cardiac sarcoidosis develops as noncaseating granulomas which may involve the left ventricular free wall, basal ventricular septum, right ventricle, papillary muscles, right atrium, and left atrium. Cardiac involvement occurs in 20–27 % of sarcoidosis patients in the United States and may be as high as 58 % in Japan.

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Author information

Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, National Jewish Health, 1400 Jackson St., Denver, CO, 80206, USA

    Andrew M. Freeman MD, FACC, FACP

Authors
  1. Andrew M. Freeman MD, FACC, FACP
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Correspondence to Andrew M. Freeman MD, FACC, FACP .

Editor information

Editors and Affiliations

  1. Department of Medicine Division of Cardiology, National Jewish Health, Denver, Colorado, USA

    Andrew M. Freeman

  2. Department of Medicine Division of Cardiology, National Jewish Health, Denver, Colorado, USA

    Howard D. Weinberger

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© 2015 Springer International Publishing Switzerland

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Freeman, A.M. (2015). Pathophysiology: From Genetics to Viruses and More. In: Freeman, A., Weinberger, H. (eds) Cardiac Sarcoidosis. Springer, Cham. https://doi.org/10.1007/978-3-319-14624-9_2

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  • DOI: https://doi.org/10.1007/978-3-319-14624-9_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-14623-2

  • Online ISBN: 978-3-319-14624-9

  • eBook Packages: MedicineMedicine (R0)

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