Abstract
Kidney transplantation represents the best option of renal replacement therapy with a 93 % first year graft survival rate and graft half-life reaching 10 years at most centers. Nevertheless, chronic rejection mediated by antibodies represents by far the most important cause of kidney grafts failure in the long-term follow-up while acute rejection affects 10–20 % of kidney allografts early after transplantation. The chapter briefly describes rejection models and models of renal failure and the procedures of kidney graft procurement and transplantation. Models used in kidney transplantation are divided into the models studying rejection (chronic, acute, antibody mediated) and models studying specific process of kidney graft damage (ischemia reperfusion injury, membranous changes, kidney failure, antibody mediated changes, toxic effects of single drugs). Kidney graft procurement and kidney graft transplant procedure are described step by step in detail with photos at important steps.
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Viklicky, O., Girmanova, E., Balaz, P. (2015). Kidney Transplantation. In: Girman, P., Kriz, J., Balaz, P. (eds) Rat Experimental Transplantation Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-14559-4_8
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DOI: https://doi.org/10.1007/978-3-319-14559-4_8
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-14558-7
Online ISBN: 978-3-319-14559-4
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