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Protein Kinase CK2 Cellular Function in Normal and Disease States pp 141–157Cite as

Cellular Zinc Signalling Is Triggered by CK2

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 12))

Abstract

Zinc is an essential trace element involved in various biological processes. Too much or too little cellular free zinc can cause detrimental effects and cell death. The intracellular level of zinc is controlled by three groups of proteins: ZnT transporters (SLC30A, zinc exporters), ZIP channels (SLC39A, zinc importers) and zinc-binding proteins such as metallothioneins. Zinc channel, ZIP7, a hub of zinc release from the stores, has long been associated with aggressiveness and development of anti-endocrine resistance in breast cancer. However, little is known about its regulatory mechanism. Recently, we have demonstrated that this ZIP channel is post-translationally triggered by CK2 phosphorylation on two cytoplasmic residues resulting in zinc release from the stores and activation of downstream effectors which lead to cancer growth. This CK2-triggered zinc release acts to inhibit multiple protein tyrosine phosphatases, resulting in direct stimulation of normal growth, migration and, in increased amounts, also cancer growth. Interestingly, another ZIP channel, ZIP6, with a known role in EMT and cancer metastasis is also predicted to be phosphorylated by CK2. ZIP channels are therefore new substrates of CK2 that may help explain CK2-related cancer phenotypes, including cell proliferation, cell migration and metastasis.

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Authors and Affiliations

  1. Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK

    Thirayost Nimmanon & Kathryn M. Taylor

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  1. Thirayost Nimmanon
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Editors and Affiliations

  1. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, Minnesota, USA

    Khalil Ahmed

  2. Dept of Biochemistry & Molecular Biology, University of Southern Denmark, Odense, Denmark

    Olaf-Georg Issinger

  3. Department of Molecular Biology, The John Paul II Catholic U. of Lublin Institute of Biotechnology, Lublin, Poland

    Ryszard Szyszka

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Nimmanon, T., Taylor, K.M. (2015). Cellular Zinc Signalling Is Triggered by CK2. In: Ahmed, K., Issinger, OG., Szyszka, R. (eds) Protein Kinase CK2 Cellular Function in Normal and Disease States. Advances in Biochemistry in Health and Disease, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-14544-0_9

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