Abstract
In this chapter we will discuss genome wide association studies (GWAS) using SNP. GWAS present some challenges for biostatistics and bioinformatics—the sheer dimensionality of the data can create storage/retrieval and analysis problems. Quality control and data preprocessing are also important steps in GWAS. We will initially discuss basic database usage for data storage and handling and the main metrics for evaluating the quality of genotypes followed by how to perform a GWAS, multiple testing issues and how to visualize results.
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Gondro, C. (2015). Genome Wide Association Studies. In: Primer to Analysis of Genomic Data Using R. Use R!. Springer, Cham. https://doi.org/10.1007/978-3-319-14475-7_3
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DOI: https://doi.org/10.1007/978-3-319-14475-7_3
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