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Front-to-Rear Polarity in Migrating Cells

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Cell Polarity 1

Abstract

Cell migration is a polarised cellular function involved both during development and in the adult where it participates to immune reaction, wound healing, tissue renewal, as well as cancer spreading. Migrating cells display a characteristic protruding front, at the opposite of a retracting trailing edge. This front-to-rear functional polarity, paralleled by the polarised morphology of the cell, reflects the polarisation of the intracellular organisation and signalling cascades. Random migration only requires the establishment of front-to-rear polarity; in contrast, the directed and persistent migration, as observed in vivo, necessitates the orientation of the front-to-rear polarity axis in a direction governed by multiple polarity cues found in the cell environment and the maintenance of the front-to-rear axis over time. This chapter summarises the characteristics of polarised migrating cells and presents the molecular mechanisms at the heart of the initiation, the orientation and the maintenance of front-to-rear polarity.

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Authors and Affiliations

  1. Cell Polarity, Migration and Cancer Unit, Institut Pasteur - CNRS UMR 3691, 25 rue du Dr Roux, 75724, Paris Cedex 15, France

    Flora Llense & Sandrine Etienne-Manneville

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  1. Flora Llense
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  2. Sandrine Etienne-Manneville
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Correspondence to Sandrine Etienne-Manneville .

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  1. Institute-associated Research Group “Cell Adhesion and Cell Polarity”, Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation (ZMBE), University Münster, Münster, Nordrhein-Westfalen, Germany

    Klaus Ebnet

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Llense, F., Etienne-Manneville, S. (2015). Front-to-Rear Polarity in Migrating Cells. In: Ebnet, K. (eds) Cell Polarity 1. Springer, Cham. https://doi.org/10.1007/978-3-319-14463-4_5

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