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Protein Trafficking in Polarized Epithelial Cells

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Cell Polarity 1

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Abstract

The architecture of epithelial cells comprises the separation of the plasma membrane into two separately composed compartments, the apical and the basolateral membrane. This concept is maintained by a sorting and transport machinery which verifies targeting of lipid and protein components to the correct membrane domain. Different intracellular routes, a heterogeneous population of sorting signals, and cellular factors associated with polarized trafficking are discussed.

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  1. Department of Cell Biology and Cell Pathology, Philipps-University Marburg, Robert-Koch-Str. 6, Marburg, 35037, Germany

    Sabrina Zink & Ralf Jacob

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  1. Sabrina Zink
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  2. Ralf Jacob
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Correspondence to Ralf Jacob .

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  1. Institute-associated Research Group “Cell Adhesion and Cell Polarity”, Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation (ZMBE), University Münster, Münster, Nordrhein-Westfalen, Germany

    Klaus Ebnet

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Zink, S., Jacob, R. (2015). Protein Trafficking in Polarized Epithelial Cells. In: Ebnet, K. (eds) Cell Polarity 1. Springer, Cham. https://doi.org/10.1007/978-3-319-14463-4_16

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