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Immunological Synapse Formation: Cell Polarity During T Cell–APC Interaction

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Cell Polarity 1

Abstract

Intercellular communication is essential for coordinating a successful immune response. The immunological synapse provides a platform for such communication by coupling activated lymphocytes specifically to their target cells. The formation of an IS in T cells is triggered by stimulation of the T cell antigen receptor and depends on the rapid and polarized remodeling of the cytoskeleton. This dramatic change in cell polarity is required to achieve optimal T cell activation and function. In this chapter, we will discuss the structure of the IS, how it forms, and how it contributes to T cell function during immune responses.

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Authors and Affiliations

  1. Immunology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 514, New York, NY, 10065, USA

    Xin Liu & Morgan Huse

  2. Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, 10065, USA

    Xin Liu

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  1. Institute-associated Research Group “Cell Adhesion and Cell Polarity”, Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation (ZMBE), University Münster, Münster, Nordrhein-Westfalen, Germany

    Klaus Ebnet

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Liu, X., Huse, M. (2015). Immunological Synapse Formation: Cell Polarity During T Cell–APC Interaction. In: Ebnet, K. (eds) Cell Polarity 1. Springer, Cham. https://doi.org/10.1007/978-3-319-14463-4_11

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