Abstract
Diffusion magnetic resonance imaging (dMRI) provides a non-invasive tool to explore biological tissues, including brain with its highly organised hierarchical fibrous structures. An MR phantom is a test object with known size and material for the calibration of MR scanners and the validation of image processing algorithms. Despite extensive research on the development of brain-mimicking phantoms, there are significant problems with using the existing phantoms for dMRI. This chapter is designed to lead the reader through the development of brain-mimetic phantoms for application in dMRI. Our starting point is a brief introduction to the dMRI technique and phantoms previously developed to mimic brain tissues. The second section focuses on the preparation and characterization of novel physical phantoms composed of co-electrospun hollow microfibres. Finally, the evaluation of the developed co-electrospun phantoms is presented in the third section.
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Acknowledgments
The research was partly funded by the project FP7 “CONNECT” (grant number 238292), by a research grant from Philips Healthcare and by CRUK-EPSRC Cancer Imaging Centre in Cambridge and Manchester.
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Zhou, FL., Hubbard Cristinacce, P.L., Eichhorn, S.J., Parker, G.J.M. (2015). Co-electrospun Brain Mimetic Hollow Microfibres Fibres for Diffusion Magnetic Resonance Imaging. In: Macagnano, A., Zampetti, E., Kny, E. (eds) Electrospinning for High Performance Sensors. NanoScience and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-14406-1_12
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