Abstract
Extraintestinal manifestations are commonly reported in patients with Crohn’s disease (CD). Extraintestinal manifestations are thought to be immune-related manifestations of CD and can virtually involve any organ system. The most common organs affected are the joints, eyes, skin, and hepatobiliary tract. Extraintestinal manifestations may or may not parallel underlying CD activity. The symptoms due to extraintestinal manifestations of disease can occur before, concurrently, or after the diagnosis of CD.
This chapter reviews the most common extraintestinal manifestations as well as some common complications that occur as a direct result of CD or medications used for the treatment of CD.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Steer S, et al. Low back pain, sacroiliitis, and the relationship with HLA-B27 in Crohn’s disease. J Rheumatol. 2003;30:518–22.
Orchard T, Wordsworth B, Jewell D. Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history. Gut. 1998;42:387–91. doi:10.1136/gut.42.3.387.
Bernstein C, Leslie W, Leboff M. AGA technical review on osteoporosis in gastrointestinal diseases. Gastroenterology. 2003;124:795–841. doi:10.1053/gast.2003.50106.
Orchard T, et al. Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes. Gastroenterology. 2002;123:714–8. doi:10.1053/gast.2002.35396.
Agarwal A, Andrews J. Systematic review: IBD-associated pyoderma gangrenosum in the biologic era, the response to therapy. Aliment Pharmacol Ther. 2013;38:563–72. doi:10.1111/apt.12431.
Ampuero J, Rojas-Feria M, Castro-Fernández M, Cano C, Romero-Gómez M. Predictive factors for erythema nodosum and pyoderma gangrenosum in inflammatory bowel disease. J Gastroenterol Hepatol. 2014;29:291–5. doi:10.1111/jgh.12352.
Cullen G, Kroshinsky D, Cheifetz A, Korzenik J. Psoriasis associated with anti-tumour necrosis factor therapy in inflammatory bowel disease: a new series and a review of 120 cases from the literature. Aliment Pharmacol Ther. 2011;34:1318–27. doi:10.1111/j.1365-2036.2011.04866.x.
Singh S, Talwalkar J. Primary sclerosing cholangitis: diagnosis, prognosis, and management. Clin Gastroenterol Hepatol. 2013;11:898–907. doi:10.1016/j.cgh.2013.02.016.
Gondim FAA, Brannagan TH, Sander HW, Chin RL, Latov N. Peripheral neuropathy in patients with inflammatory bowel disease. Brain. 2005;128:867–79. doi:10.1093/brain/awh429.
Kimura K, et al. Concurrence of inflammatory bowel disease and multiple sclerosis. Mayo Clin Proc. 2000;75:802–6. doi:10.4065/75.8.802.
Andersohn F, Waring M, Garbe E. Risk of ischemic stroke in patients with Crohn’s disease: a population-based nested case-control study. Inflamm Bowel Dis. 2010;16:1387–92. doi:10.1002/ibd.21187.
Gorelik L, et al. Anti-JC virus antibodies: implications for PML risk stratification. Ann Neurol. 2010;68:295–303. doi:10.1002/ana.22128.
Deepak P, Stobaugh D, Sherid M, Sifuentes H, Ehrenpreis E. Neurological events with tumour necrosis factor alpha inhibitors reported to the food and drug administration adverse event reporting system. Aliment Pharmacol Ther. 2013;38:388–96. doi:10.1111/apt.12385.
Ha C, Magowan S, Accortt NA, Chen J, Stone CD. Risk of arterial thrombotic events in inflammatory bowel disease. Am J Gastroenterol. 2009;104:1445–51. doi:10.1038/ajg.2009.81.
Murthy SK, Nguyen GC. Venous thromboembolism in inflammatory bowel disease: an epidemiological review. Am J Gastroenterol. 2011;106:713–8. doi:10.1038/ajg.2011.53.
Caudarella R, et al. Renal stone formation in patients with inflammatory bowel disease. Scanning Microsc. 1993;7:371.
Pitchumoni CS, Rubin A, Das K. Pancreatitis in inflam-matory bowel diseases. J Clin Gastroenterol. 2010;44:246–53. doi:10.1097/MCG.0b013e3181cadbe1.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
De Felice, K., Raffals, L.E. (2015). Extraintestinal Manifestations of Crohn’s Disease. In: Fichera, A., Krane, M. (eds) Crohn’s Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-14181-7_19
Download citation
DOI: https://doi.org/10.1007/978-3-319-14181-7_19
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-14180-0
Online ISBN: 978-3-319-14181-7
eBook Packages: MedicineMedicine (R0)