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PARP Inhibitors for Cancer Therapy pp 99–124Cite as

PARP and Carcinogenesis

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D,volume 83))

Abstract

Cancer is a complex disease that results from the successive accumulation of genetic and epigenetic alterations. These, together with transcriptional deregulation, and aberrations in post-translational modification, are the forces driving carcinogenesis. During the carcinogenesis, cells suffer environmental stress and genetic, epigenetic and other changes are induced, with each of these changes affecting further evolution of cancerous cells. Blocking these changes is important for cancer prevention and treatment. For couples of decades, poly(ADP-ribosylation) (PARylation) in the processes of carcinogenesis has been studied by using various models and human genetic and epidemiological studies and further mechanistic analysis at the molecular, cellular and in vivo levels has been conducted. The obtained evidence is being utilized for establishing effective and non-invasive strategies for cancer prevention. In this review we discuss how PARylation reaction and related molecules are involved in multi-step carcinogenesis. Molecules function in PARylation and involved in carcinogenesis are listed in Table 5.1.

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Acknowledgements

This work was supported in part by the Third Term Comprehensive 10-Year Strategy for Cancer Control (10103833) from the Ministry of Health, Labor and Welfare of Japan, from the MEXT of Japan (22300343), and a Grant-in-Aid for Cancer Research from the Princess Takamatsu Cancer Research Fund.

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Authors and Affiliations

  1. Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan

    Junhui Wang, Akira Sato, Hiroaki Fujimori & Mitsuko Masutani

  2. Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan

    Junhui Wang, Hiroaki Fujimori & Mitsuko Masutani

  3. Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8510, Tokyo, Japan

    Junhui Wang & Yoshio Miki

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  1. Junhui Wang
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  1. Northern Institute for Cancer Research and Newcastle University Institute for Ageing Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

    Nicola J. Curtin

  2. CRUK-MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom

    Ricky A. Sharma

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Wang, J., Sato, A., Fujimori, H., Miki, Y., Masutani, M. (2015). PARP and Carcinogenesis. In: Curtin, N., Sharma, R. (eds) PARP Inhibitors for Cancer Therapy. Cancer Drug Discovery and Development, vol 83. Humana Press, Cham. https://doi.org/10.1007/978-3-319-14151-0_5

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