Abstract
Cancer chemotherapy is indeed indebted to microorganisms and their products, antibiotics. Since the discovery of the first antibiotic with anticancer properties, a lot of research has been focused on isolation, modification, partial or total synthesis, as well as uncovering the mechanism of action, increasing the efficacy, and meanwhile reducing the toxicity of these potential metabolites. Different classes of antibiotics such as aromatic polyketides (anthracyclines), glycopeptides (bleomycins), indolocarbazoles, etc. have presented effective medications to fight against cancer. The effort is continuing and a number of promising drugs from a variety of classes are under clinical investigations for future establishment in the cancer chemotherapy regimen.
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Saeidnia, S. (2015). Anticancer Antibiotics. In: New Approaches to Natural Anticancer Drugs. SpringerBriefs in Pharmaceutical Science & Drug Development. Springer, Cham. https://doi.org/10.1007/978-3-319-14027-8_4
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