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Topical Chemotherapy

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Book cover Upper Urinary Tract Urothelial Carcinoma

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Abstract

The use of topical chemotherapy is well established in transitional cell carcinoma (TCC) of the bladder. The same urothelial surface is present in the upper tract and has stimulated interest in treating patients in the same manner with access via an antegrade nephrostomy tube or retrograde ureteral catheter or double pigtail stent. Bacillus Calmette- Guérin (BCG) has been most widely investigated with promising results for treatment of primary CIS. It has also been used in the adjuvant setting after endoscopic treatment along with mitomycin-C, thiotepa and interferon-α2. The comparative rarity of UTUC has led to a small body of evidence from which to draw meaningful conclusions. Further, prospective randomised studies are required to better define treatment benefit, side effects and optimal follow-up schedule.

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Authors and Affiliations

  1. Bristol Urological Institute, Southmead Hospital, Bristol, UK

    John Michael Henderson BMBS, BMedSci(Hons), FRCS, FEBU & Francis X. Keeley Jr. MD, FRCS (Urol)

Authors
  1. John Michael Henderson BMBS, BMedSci(Hons), FRCS, FEBU
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  2. Francis X. Keeley Jr. MD, FRCS (Urol)
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Corresponding author

Correspondence to John Michael Henderson BMBS, BMedSci(Hons), FRCS, FEBU .

Editor information

Editors and Affiliations

  1. Lenox Hill Hospital, Department of Urology, New York Medical College, Valhala, New York, New York, New York, USA

    Michael Grasso III

  2. Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Demetrius H. Bagley

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© 2015 Springer International Publishing Switzerland

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Henderson, J.M., Keeley, F.X. (2015). Topical Chemotherapy. In: Grasso III, M., Bagley, D. (eds) Upper Urinary Tract Urothelial Carcinoma. Springer, Cham. https://doi.org/10.1007/978-3-319-13869-5_7

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  • DOI: https://doi.org/10.1007/978-3-319-13869-5_7

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-13868-8

  • Online ISBN: 978-3-319-13869-5

  • eBook Packages: MedicineMedicine (R0)

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