Abstract
Infections remain a cause of significant morbidity and mortality following hematopoietic stem cell transplantation (HSCT). The conditioning regimen (chemotherapy, radiation therapy), mucosal damage, type of transplant, immune suppressive therapy, and graft-versus-host disease (GVHD) all predispose the HSCT recipient to infection. Abnormal B and T lymphocyte function results in impaired humoral and cellular immunity, respectively. Humoral defects can predispose a patient to infection with pyogenic organisms and other bacteria as well as viral infections. Neutrophil function is impaired by the use of corticosteroids and other medications. Hypogammaglobulinemia and functional asplenia are common. The occurrence of infections in an individual patient varies according to the phase of the transplant process and reflects the type(s) of immune defect(s), underlying disease, endogenous host flora, exposure history, and pretreatment infections.
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Strasfeld, L. (2015). Infection Prophylaxis. In: Maziarz, R., Slater, S. (eds) Blood and Marrow Transplant Handbook. Springer, Cham. https://doi.org/10.1007/978-3-319-13832-9_10
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DOI: https://doi.org/10.1007/978-3-319-13832-9_10
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