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Part of the book series: Annual Update in Intensive Care and Emergency Medicine 2015 ((AUICEM,volume 2015))

Abstract

Improvements in neurosurgical and neurological intensive care have led to increased numbers of survivors from severe traumatic brain injury (TBI). Following coma, some patients undergo transition into prolonged disorders of consciousness, including minimally conscious state (MCS) and the unresponsive wakefulness syndrome (UWS) [1]. The clinical hallmarks of consciousness are arousal and awareness. In chronic disorders of consciousness, patients commonly reestablish subcortical functions of arousal, but with decline or absence of cortical functions, leading to loss of awareness. Whereas UWS patients show no responsiveness at the bedside, MCS patients elicit fluctuating but reproducible signs of awareness of their surroundings. By convention, emergence from MCS occurs when the patient regains a capacity for functional communication or object use. Long-term recovery of consciousness from UWS remains uncertain, but progression into MCS is an important indicator of better prognosis.

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References

  1. Giacino JT (2004) The vegetative and minimally conscious states: consensus-based criteria for establishing diagnosis and prognosis. NeuroRehabilitation 19:293–298

    PubMed  Google Scholar 

  2. Boly M, Faymonville ME, Schnakers C et al (2008) Perception of pain in the minimally conscious state with PET activation: an observational study. Lancet Neurol 7:1013–1020

    Article  PubMed  Google Scholar 

  3. Bekinschtein T, Leiguarda R, Armony J et al (2004) Emotion processing in the minimally conscious state. J Neurol Neurosurg Psychiatr 75:788

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Chatelle C, Thibaut A, Whyte J, De Val MD, Laureys S, Schnakers C (2014) Pain issues in disorders of consciousness. Brain Injury 28:1202–1208

    Article  PubMed  Google Scholar 

  5. Luauté J, Maucort-Boulch D, Tell L et al (2010) Long-term outcomes of chronic minimally conscious and vegetative states. Neurology 75:246–252

    Article  PubMed  Google Scholar 

  6. Estraneo A, Moretta P, Loreto V, Lanzillo B, Santoro L, Trojano L (2010) Late recovery after traumatic, anoxic, or hemorrhagic long-lasting vegetative state. Neurology 75:239–245

    Article  CAS  PubMed  Google Scholar 

  7. Thibaut A, Bruno M-A, Ledoux D, Demertzi A, Laureys S (2014) tDCS in patients with disorders of consciousness: sham-controlled randomized double-blind study. Neurology 82:1112–1118

    Article  PubMed  Google Scholar 

  8. Schiff ND, Giacino JT, Kalmar K et al (2007) Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 448:600–603

    Article  CAS  PubMed  Google Scholar 

  9. Manning J (2012) Withdrawal of life-sustaining treatment from a patient in a minimally conscious state. J Law Med 19:430–435

    PubMed  Google Scholar 

  10. Stender J, Gosseries O, Bruno MA et al (2014) Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study. Lancet 384:514–522

    Article  PubMed  Google Scholar 

  11. Schnakers C, Vanhaudenhuyse A, Giacino J et al (2009) Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment. BMC Neurol 9:35

    Article  PubMed Central  PubMed  Google Scholar 

  12. Giacino JT, Kalmar K, Whyte J (2004) The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility. Arch Phys Med Rehab 85:2020–2029

    Article  Google Scholar 

  13. Kalmar K, Giacino JT (2005) The JFK Coma Recovery Scale-Revised. Neuropsychol Rehabil 15:454–460

    Article  PubMed  Google Scholar 

  14. Seel RT, Sherer M, Whyte J et al (2010) Assessment scales for disorders of consciousness: evidence-based recommendations for clinical practice and research. Arch Phys Med Rehab 91:1795–1813

    Article  Google Scholar 

  15. Bruno M-A, Vanhaudenhuyse A, Schnakers C et al (2010) Visual fixation in the vegetative state: an observational case series PET study. BMC Neurol 10:35

    Article  PubMed Central  PubMed  Google Scholar 

  16. Thonnard M, Wannez S, Keen S et al (2014) Detection of visual pursuit in patients in minimally conscious state: a matter of stimuli and visual plane? Brain Injury 28:1164–1170

    Article  PubMed  Google Scholar 

  17. Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD (2006) Detecting awareness in the vegetative state. Science 313:1402

    Article  CAS  PubMed  Google Scholar 

  18. Monti MM, Vanhaudenhuyse A, Coleman MR et al (2010) Willful modulation of brain activity in disorders of consciousness. N Engl J Med 362:579–589

    Article  CAS  PubMed  Google Scholar 

  19. Naci L, Owen AM (2013) Making every word count for nonresponsive patients. JAMA Neurol 70:1235–1241

    PubMed  Google Scholar 

  20. Naci L, Cusack R, Anello M, Owen AM (2014) A common neural code for similar conscious experiences in different individuals. 2014. Proc Natl Acad Sci USA 111:14277–14288

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Shulman RG, Hyder F, Rothman DL (2009) Baseline brain energy supports the state of consciousness. Proc Natl Acad Sci USA 106:11096–11101

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Laureys S, Owen AM, Schiff ND (2004) Brain function in coma, vegetative state, and related disorders. Lancet Neurol 3:537–546

    Article  PubMed  Google Scholar 

  23. Dehaene S, Changeux JP (2011) Experimental and theoretical approaches to conscious processing. Neuron 70:200–227

    Article  CAS  PubMed  Google Scholar 

  24. Baars BJ (2005) Global workspace theory of consciousness: toward a cognitive neuroscience of human experience. Prog Brain Res 150:45–53

    Article  PubMed  Google Scholar 

  25. Stender J, Kupers R, Rodell A et al (2015) Quantitative rates of brain glucose metabolism distinguish minimally conscious from vegetative state patients. J Cereb Blood Flow Metab (in press)

    Google Scholar 

  26. Maandag NJG, Coman D, Sanganahalli BG et al (2007) Energetics of neuronal signaling and fMRI activity. Proc Natl Acad Sci USA 104:20546–20551

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  27. Lechinger J, Bothe K, Pichler G et al (2013) CRS-R score in disorders of consciousness is strongly related to spectral EEG at rest. J Neurol 260:2348–2356

    Article  PubMed  Google Scholar 

  28. Sitt JD, King J-R, Karoui El I et al (2014) Large scale screening of neural signatures of consciousness in patients in a vegetative or minimally conscious state. Brain 137:2258–2270

    Article  PubMed  Google Scholar 

  29. Tononi G (2008) Consciousness as integrated information: a provisional manifesto. Biol Bull 215:216–242

    Article  PubMed  Google Scholar 

  30. Casali AG, Gosseries O, Rosanova M et al (2013) A theoretically based index of consciousness independent of sensory processing and behavior. Sci Transl Med 5:198–105

    Article  Google Scholar 

  31. Cruse D, Gantner I, Soddu A, Owen AM (2014) Lies, damned lies and diagnoses: Estimating the clinical utility of assessments of covert awareness in the vegetative state. Brain Injury 28:1197–1201

    Article  PubMed  Google Scholar 

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Stender, J., Gjedde, A., Laureys, S. (2015). Detection of Consciousness in the Severely Injured Brain. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2015. Annual Update in Intensive Care and Emergency Medicine 2015, vol 2015. Springer, Cham. https://doi.org/10.1007/978-3-319-13761-2_36

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  • DOI: https://doi.org/10.1007/978-3-319-13761-2_36

  • Publisher Name: Springer, Cham

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