IgE Immunotherapy Against Cancer

  • Lai Sum Leoh
  • Tracy R. Daniels-WellsEmail author
  • Manuel L. PenichetEmail author
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 388)


The success of antibody therapy in cancer is consistent with the ability of these molecules to activate immune responses against tumors. Experience in clinical applications, antibody design, and advancement in technology have enabled antibodies to be engineered with enhanced efficacy against cancer cells. This allows re-evaluation of current antibody approaches dominated by antibodies of the IgG class with a new light. Antibodies of the IgE class play a central role in allergic reactions and have many properties that may be advantageous for cancer therapy. IgE-based active and passive immunotherapeutic approaches have been shown to be effective in both in vitro and in vivo models of cancer, suggesting the potential use of these approaches in humans. Further studies on the anticancer efficacy and safety profile of these IgE-based approaches are warranted in preparation for translation toward clinical application.


Mast Cell Tumor Antigen Modify Vaccinia Virus Ankara Folate Binding Protein Basophil Degranulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Our work has been supported in part by grants from NIH/NCI: R41CA137881, R01CA136841, R01CA18115, K01CA138559, R21CA179680, and the Susan G. Komen Breast Cancer Foundation Basic, Clinical and Translational Research Grant BCTR0706771.


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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Division of Surgical Oncology, Department of Surgery, David Geffen School of MedicineUniversity of California, Los AngelesLos AngelesUSA
  2. 2.Department of Microbiology, Immunology, and Molecular GeneticsUniversity of CaliforniaLos AngelesUSA
  3. 3.The Jonsson Comprehensive Cancer CenterUniversity of CaliforniaLos AngelesUSA
  4. 4.The Molecular Biology InstituteUniversity of CaliforniaLos AngelesUSA

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