Helminth-Induced IgE and Protection Against Allergic Disorders

  • Firdaus Hamid
  • Abena S. Amoah
  • Ronald van Ree
  • Maria YazdanbakhshEmail author
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 388)


The immune response against helminths and allergens is generally characterized by high levels of IgE and increased numbers of Th2 cells, eosinophils, and mast cells, yet the clinical outcome with respect to immediate hypersensitivity and inflammation is clearly not the same. High levels of IgE are seen to allergens during helminth infections; however, these IgE responses do not translate into allergy symptoms. This chapter summarizes the evidence of the association between helminth infections and allergic disorders. It discusses how helminth infection can lead to IgE cross-reactivity with allergens and how this IgE has poor biological activity. This information is important for developing new diagnostic methods and treatments for allergic disorders in low-to-middle-income countries.


Skin Prick Test Helminth Infection Mast Cell Degranulation Allergic Disorder Skin Prick Test Positivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Firdaus Hamid
    • 1
    • 2
  • Abena S. Amoah
    • 2
    • 3
  • Ronald van Ree
    • 4
  • Maria Yazdanbakhsh
    • 2
    Email author
  1. 1.Department of Microbiology, Faculty of MedicineHasanuddin UniversityMakassarIndonesia
  2. 2.Department of ParasitologyLeiden University Medical CenterLeidenThe Netherlands
  3. 3.Department of ParasitologyNoguchi Memorial Institute for Medical ResearchAccraGhana
  4. 4.Department of Experimental Immunology and Department of Otorhinolaryngology, Academic Medical CenterAmsterdam UniversityAmsterdamThe Netherlands

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