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IgE Antibodies: Generation and Function pp 63–90Cite as

New Insights on the Signaling and Function of the High-Affinity Receptor for IgE

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 388))

Abstract

Clustering of the high-affinity receptor for immunoglobulin E (FcεRI ) through the interaction of receptor-bound immunoglobulin E (IgE ) antibodies with their cognate antigen is required to couple IgE antibody production to cellular responses and physiological consequences. IgE -induced responses through FcεRI are well known to defend the host against certain infectious agents and to lead to unwanted allergic responses to normally innocuous substances. However, the cellular and/or physiological response of individuals that produce IgE antibodies may be markedly different and such antibodies (even to the same antigenic epitope) can differ in their antigen-binding affinity. How affinity variation in the interaction of FcεRI -bound IgE antibodies with antigen is interpreted into cellular responses and how the local environment may influence these responses is of interest. In this chapter, we focus on recent advances that begin to unravel how FcεRI distinguishes differences in the affinity of IgE –antigen interactions and how such discrimination along with surrounding environmental stimuli can shape the (patho) physiological response.

The studies of the authors herein described were supported by the Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health.

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Abbreviations

BCR:

B cell receptor

BTK:

Bruton’s tyrosine kinase

CBMC:

Cord blood-derived mast cells

DAG:

Diacylglycerol

DNP:

Dinitrophenyl

ERK:

Extracellular signal-regulated kinase

FcεRI:

High-affinity receptor for immunoglobulin E

FRAP:

Fluorescence recovery after photobleaching

FSMC:

Fetal skin-derived mast cells

GAB2:

GRB2-associated-binding protein 2

GFP:

Green fluorescent protein

GIRKs:

G-protein-coupled inwardly rectifying potassium channels

GM-CSF:

Granulocyte macrophage colony-stimulating factor

HC:

Highly cytokinergic

HSA:

Human serum albumin

IgE:

Immunoglobulin E

IP3:

Inositol 1,4,5, triphosphate

ITAM:

Immunoreceptor tyrosine-based activation motif

ITIM:

Immunoreceptor tyrosine-based inhibitory motif

JNK:

c-Jun N-terminal protein kinase

LAT1:

Linker for activation of T cells

LAT2:

Linker for activation of T cells family, member 2

LIF:

Leukemia inhibitory factor

LTC4:

Leukotriene C4

MAP Kinase:

Mitogen-activated protein kinase

MCP-1:

Monocyte chemoattractant protein-1

MIP-1:

Macrophage inflammatory proteins-1

MITF:

Microphthalmia transcription factor

NFAT:

Nuclear factor of activated T cells

PC:

Poorly cytokinergic

PCA:

Passive cutaneous anaphylaxis

PI3-K:

Phosphoinositide 3-kinase

PIP:

Phosphatidylinositol 4,5 bisphosphate

PKC:

Protein kinase C

PLC:

Phospholipase C

PTK:

Protein tyrosine kinase

QD:

Quantum dot

RBL-2H3:

Rat basophilic leukemia subclone-2H3

STAT:

Signal transducer and activator of transcription

Syk:

Spleen tyrosine kinase

TIRF:

Total internal reflection fluorescence

TLR:

Toll-like receptor

TNF:

Tumor necrosis factor

TRB3:

Tribbles homolog 3

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Molecular Immunology Section, Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    Ryo Suzuki, Jörg Scheffel & Juan Rivera

  2. NIAMS-NIH, Building 10, Rm 13C103, Bethesda, MD, 20892, USA

    Juan Rivera

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  1. Ryo Suzuki
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  2. Jörg Scheffel
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  3. Juan Rivera
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Correspondence to Juan Rivera .

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  1. Skirball Institute and Department of Pathology, New York University School of Medicine, New York, USA

    Juan J. Lafaille

  2. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore

    Maria A. Curotto de Lafaille

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Suzuki, R., Scheffel, J., Rivera, J. (2015). New Insights on the Signaling and Function of the High-Affinity Receptor for IgE. In: Lafaille, J., Curotto de Lafaille, M. (eds) IgE Antibodies: Generation and Function. Current Topics in Microbiology and Immunology, vol 388. Springer, Cham. https://doi.org/10.1007/978-3-319-13725-4_4

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