New Insights on the Signaling and Function of the High-Affinity Receptor for IgE

  • Ryo Suzuki
  • Jörg Scheffel
  • Juan RiveraEmail author
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 388)


Clustering of the high-affinity receptor for immunoglobulin E (FcεRI ) through the interaction of receptor-bound immunoglobulin E (IgE ) antibodies with their cognate antigen is required to couple IgE antibody production to cellular responses and physiological consequences. IgE -induced responses through FcεRI are well known to defend the host against certain infectious agents and to lead to unwanted allergic responses to normally innocuous substances. However, the cellular and/or physiological response of individuals that produce IgE antibodies may be markedly different and such antibodies (even to the same antigenic epitope) can differ in their antigen-binding affinity. How affinity variation in the interaction of FcεRI -bound IgE antibodies with antigen is interpreted into cellular responses and how the local environment may influence these responses is of interest. In this chapter, we focus on recent advances that begin to unravel how FcεRI distinguishes differences in the affinity of IgE –antigen interactions and how such discrimination along with surrounding environmental stimuli can shape the (patho) physiological response.


Mast Cell Mast Cell Degranulation Human Mast Cell Total Internal Reflection Fluorescence Microscopy Brutons Tyrosine Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



B cell receptor


Bruton’s tyrosine kinase


Cord blood-derived mast cells






Extracellular signal-regulated kinase


High-affinity receptor for immunoglobulin E


Fluorescence recovery after photobleaching


Fetal skin-derived mast cells


GRB2-associated-binding protein 2


Green fluorescent protein


G-protein-coupled inwardly rectifying potassium channels


Granulocyte macrophage colony-stimulating factor


Highly cytokinergic


Human serum albumin


Immunoglobulin E


Inositol 1,4,5, triphosphate


Immunoreceptor tyrosine-based activation motif


Immunoreceptor tyrosine-based inhibitory motif


c-Jun N-terminal protein kinase


Linker for activation of T cells


Linker for activation of T cells family, member 2


Leukemia inhibitory factor


Leukotriene C4

MAP Kinase

Mitogen-activated protein kinase


Monocyte chemoattractant protein-1


Macrophage inflammatory proteins-1


Microphthalmia transcription factor


Nuclear factor of activated T cells


Poorly cytokinergic


Passive cutaneous anaphylaxis


Phosphoinositide 3-kinase


Phosphatidylinositol 4,5 bisphosphate


Protein kinase C


Phospholipase C


Protein tyrosine kinase


Quantum dot


Rat basophilic leukemia subclone-2H3


Signal transducer and activator of transcription


Spleen tyrosine kinase


Total internal reflection fluorescence


Toll-like receptor


Tumor necrosis factor


Tribbles homolog 3


Vascular endothelial growth factor


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Molecular Immunology Section, Laboratory of Molecular ImmunogeneticsNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of HealthBethesdaUSA
  2. 2.NIAMS-NIHBethesdaUSA

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