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Biology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses

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IgE Antibodies: Generation and Function

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 388))

Abstract

The generation of long-lived plasma cells and memory B cells producing high-affinity antibodies depends on the maturation of B cell responses in germinal centers. These processes are essential for long-lasting antibody-mediated protection against infections. IgE antibodies are important for defense against parasites and toxins and can also mediate anti-tumor immunity. However, high-affinity IgE is also the main culprit responsible for the manifestations of allergic disease, including life-threatening anaphylaxis . Thus, generation of high-affinity IgE must be tightly regulated. Recent studies of IgE B cell biology have unveiled two mechanisms that limit high-affinity IgE memory responses: First, B cells that have recently switched to IgE production are programmed to rapidly differentiate into plasma cells, and second, IgE germinal center cells are transient and highly apoptotic. Opposing these processes, we now know that germinal center-derived IgG B cells can switch to IgE production, effectively becoming IgE-producing plasma cells. In this chapter, we will discuss the unique molecular and cellular pathways involved in the generation of IgE antibodies.

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Abbreviations

AID:

Activation-induced cytidine deaminase

BCR:

B cell receptor

CSR:

Class switch recombination

EMPD:

Extra membrane proximal domain

GC:

Germinal center

LN:

Lymph node

PC:

Plasma cell

TLR:

Toll-like receptor

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Acknowledgments

MACL laboratory is supported by A*STAR-SIgN core funding and by the Joint Council Organization (JCO) grant 1431AFG104, Singapore. J.J. Lafaille laboratory is supported by the Multiple Sclerosis Society, a B Levine scholarship and the NIH. We wish to thank Dr Lucy Robinson of Insight Editing London for her assistance in the preparation of the text.

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Authors and Affiliations

  1. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore

    Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho & Maria A. Curotto de Lafaille

  2. Nanyang Technological University, School of Biological Sciences, Singapore, Singapore

    Sharrada Subramaniam

  3. Skirball Institute and Department of Pathology, New York University School of Medicine, New York, USA

    Juan J. Lafaille

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  1. Jin-Shu He
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  2. Sriram Narayanan
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  3. Sharrada Subramaniam
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  4. Wen Qi Ho
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  5. Juan J. Lafaille
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  6. Maria A. Curotto de Lafaille
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Correspondence to Maria A. Curotto de Lafaille .

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Editors and Affiliations

  1. Skirball Institute and Department of Pathology, New York University School of Medicine, New York, USA

    Juan J. Lafaille

  2. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore

    Maria A. Curotto de Lafaille

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He, JS., Narayanan, S., Subramaniam, S., Ho, W.Q., Lafaille, J.J., Curotto de Lafaille, M.A. (2015). Biology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses. In: Lafaille, J., Curotto de Lafaille, M. (eds) IgE Antibodies: Generation and Function. Current Topics in Microbiology and Immunology, vol 388. Springer, Cham. https://doi.org/10.1007/978-3-319-13725-4_1

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