Biology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses
The generation of long-lived plasma cells and memory B cells producing high-affinity antibodies depends on the maturation of B cell responses in germinal centers. These processes are essential for long-lasting antibody-mediated protection against infections. IgE antibodies are important for defense against parasites and toxins and can also mediate anti-tumor immunity. However, high-affinity IgE is also the main culprit responsible for the manifestations of allergic disease, including life-threatening anaphylaxis . Thus, generation of high-affinity IgE must be tightly regulated. Recent studies of IgE B cell biology have unveiled two mechanisms that limit high-affinity IgE memory responses: First, B cells that have recently switched to IgE production are programmed to rapidly differentiate into plasma cells, and second, IgE germinal center cells are transient and highly apoptotic. Opposing these processes, we now know that germinal center-derived IgG B cells can switch to IgE production, effectively becoming IgE-producing plasma cells. In this chapter, we will discuss the unique molecular and cellular pathways involved in the generation of IgE antibodies.
KeywordsClass Switching Dark Zone Class Switch Recombination Switch Region Sequential Switching
Activation-induced cytidine deaminase
B cell receptor
Class switch recombination
Extra membrane proximal domain
MACL laboratory is supported by A*STAR-SIgN core funding and by the Joint Council Organization (JCO) grant 1431AFG104, Singapore. J.J. Lafaille laboratory is supported by the Multiple Sclerosis Society, a B Levine scholarship and the NIH. We wish to thank Dr Lucy Robinson of Insight Editing London for her assistance in the preparation of the text.
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